Moein Amin , Kunio Nakamura , Lynn Daboul , Carly O'Donnell , Quy Cao , Paulo Rodrigues , John Derbyshire , Christina Azevedo , Amit Bar-Or , Eduardo Caverzasi , Peter A. Calabresi , Bruce A.C. Cree , Leorah Freeman , Roland Henry , Erin E. Longbrake , Jiwon Oh , Nico Papinutto , Daniel Pelletier , Vesna Prčkovska , Praneeta C. Raza , Daniel Ontaneda
{"title":"将中心静脉征象纳入麦当劳标准","authors":"Moein Amin , Kunio Nakamura , Lynn Daboul , Carly O'Donnell , Quy Cao , Paulo Rodrigues , John Derbyshire , Christina Azevedo , Amit Bar-Or , Eduardo Caverzasi , Peter A. Calabresi , Bruce A.C. Cree , Leorah Freeman , Roland Henry , Erin E. Longbrake , Jiwon Oh , Nico Papinutto , Daniel Pelletier , Vesna Prčkovska , Praneeta C. Raza , Daniel Ontaneda","doi":"10.1016/j.msard.2024.106182","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.</div></div><div><h3>Objective</h3><div>Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.</div></div><div><h3>Methods</h3><div>Data were obtained from the CAVS-MS Pilot, a cross-sectional, international multi-center study conducted by the North American Imaging in MS Cooperative (NAIMS) that recruited adults referred for suspicion/diagnosis of demyelinating disease. Diagnostic performance of methods incorporating CVS into McD 2017 radiological DIS were evaluated by comparing sensitivity, specificity, and accuracy.</div></div><div><h3>Results</h3><div>78 participants (37 MS, 41 others) were included. For MS diagnosis, sensitivity, specificity, and accuracy of DIS based on brain imaging (DIS-B) alone was 92 %, 69 %, and 78 %. Requiring at least one lesion with CVS in any brain location in addition to DIS-B increased specificity (sensitivity 92 %, specificity 81 %, accuracy 86 %). Presence of 2 deep white matter lesions with CVS as an additional topography for DIS-B had higher sensitivity (sensitivity 97 %, specificity 59 %, accuracy 77 %).</div></div><div><h3>Conclusions</h3><div>Incorporation of CVS in McD 2017 DIS criteria can be used to improve diagnostic accuracy. Validation in additional prospective studies is needed.</div></div>","PeriodicalId":18958,"journal":{"name":"Multiple sclerosis and related disorders","volume":"93 ","pages":"Article 106182"},"PeriodicalIF":3.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incorporation of the central vein sign into the McDonald criteria\",\"authors\":\"Moein Amin , Kunio Nakamura , Lynn Daboul , Carly O'Donnell , Quy Cao , Paulo Rodrigues , John Derbyshire , Christina Azevedo , Amit Bar-Or , Eduardo Caverzasi , Peter A. Calabresi , Bruce A.C. Cree , Leorah Freeman , Roland Henry , Erin E. Longbrake , Jiwon Oh , Nico Papinutto , Daniel Pelletier , Vesna Prčkovska , Praneeta C. Raza , Daniel Ontaneda\",\"doi\":\"10.1016/j.msard.2024.106182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.</div></div><div><h3>Objective</h3><div>Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.</div></div><div><h3>Methods</h3><div>Data were obtained from the CAVS-MS Pilot, a cross-sectional, international multi-center study conducted by the North American Imaging in MS Cooperative (NAIMS) that recruited adults referred for suspicion/diagnosis of demyelinating disease. Diagnostic performance of methods incorporating CVS into McD 2017 radiological DIS were evaluated by comparing sensitivity, specificity, and accuracy.</div></div><div><h3>Results</h3><div>78 participants (37 MS, 41 others) were included. For MS diagnosis, sensitivity, specificity, and accuracy of DIS based on brain imaging (DIS-B) alone was 92 %, 69 %, and 78 %. Requiring at least one lesion with CVS in any brain location in addition to DIS-B increased specificity (sensitivity 92 %, specificity 81 %, accuracy 86 %). Presence of 2 deep white matter lesions with CVS as an additional topography for DIS-B had higher sensitivity (sensitivity 97 %, specificity 59 %, accuracy 77 %).</div></div><div><h3>Conclusions</h3><div>Incorporation of CVS in McD 2017 DIS criteria can be used to improve diagnostic accuracy. Validation in additional prospective studies is needed.</div></div>\",\"PeriodicalId\":18958,\"journal\":{\"name\":\"Multiple sclerosis and related disorders\",\"volume\":\"93 \",\"pages\":\"Article 106182\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple sclerosis and related disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211034824007582\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple sclerosis and related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211034824007582","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Incorporation of the central vein sign into the McDonald criteria
Background
Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.
Objective
Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.
Methods
Data were obtained from the CAVS-MS Pilot, a cross-sectional, international multi-center study conducted by the North American Imaging in MS Cooperative (NAIMS) that recruited adults referred for suspicion/diagnosis of demyelinating disease. Diagnostic performance of methods incorporating CVS into McD 2017 radiological DIS were evaluated by comparing sensitivity, specificity, and accuracy.
Results
78 participants (37 MS, 41 others) were included. For MS diagnosis, sensitivity, specificity, and accuracy of DIS based on brain imaging (DIS-B) alone was 92 %, 69 %, and 78 %. Requiring at least one lesion with CVS in any brain location in addition to DIS-B increased specificity (sensitivity 92 %, specificity 81 %, accuracy 86 %). Presence of 2 deep white matter lesions with CVS as an additional topography for DIS-B had higher sensitivity (sensitivity 97 %, specificity 59 %, accuracy 77 %).
Conclusions
Incorporation of CVS in McD 2017 DIS criteria can be used to improve diagnostic accuracy. Validation in additional prospective studies is needed.
期刊介绍：
Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource.
A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.
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