津巴布韦霍乱暴发:对药用植物的驱动因素、制约因素和重新构想的深入分析。

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2024-11-21 eCollection Date: 2024-01-01 DOI:10.1155/jotm/1981991
Jerikias Marumure, Monde A Nyila
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引用次数: 0

摘要

霍乱是一种由霍乱弧菌引起的肠道感染,对公众健康构成严重威胁,特别是在发展中国家。本述评讨论了津巴布韦霍乱暴发的驱动因素、挑战和可行的替代办法。文献检索使用电子数据库,特别是ScienceDirect, b谷歌Scholar和PubMed,以及论文和会议论文。有证据表明,流行病学和危险因素包括:(1)极端干旱;(2)政治干预卫生问题和供水;(三)自然灾害;(4)迁移;(五)水和卫生问题;(6)病原体的地方性及其耐药性的发展。强调清洁水的可靠供应以及适当的环境卫生和个人卫生是预防的主要关键。讨论了使用抗生素和疫苗进行治疗,以及在传统医学中使用药用植物。农村社区霍乱最常见的民间治疗方法是金针叶和紫茎皮冲剂或煎剂。根据其阳性抑菌试验结果,对药用植物作为抗霍乱弧菌药物的潜力及其作用机制进行了探讨。最后,开发以天然铅和化合物为基础的创新抗霍乱弧菌疗法,并适应于资源有限的霍乱易发地区的使用,被视为一种潜在的选择,以补充霍乱的预防和治疗,特别是在资源有限的流行地区。
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Cholera Outbreaks in Zimbabwe: An In-Depth Analysis of Drivers, Constraints and Reimagining the Use of Medicinal Plants.

Cholera, an intestinal infection caused by Vibrio cholerae, poses a severe threat to public health, particularly in developing countries. This narrative review discusses drivers for cholera outbreaks, challenges and viable alternatives, in Zimbabwe. A literature search was conducted using electronic databases notably ScienceDirect, Google Scholar and PubMed, as well as thesis and conference papers. Evidence indicates that the epidemiology, as well as risk factors, includes (1) extreme droughts; (2) political meddling in health issues and water supply; (3) natural disasters; (4) migration; (5) problems with water and sanitation; and (6) the endemic nature of the causative agent as well as its development of drug resistance. Reliable supply of clean water and proper sanitation and hygiene as the main key to prevention is emphasised. The use of antibiotics and vaccines for therapy, as well as the use of medicinal plants in traditional medicine, is discussed. Kirkia acuminata and Ziziphus mucronata root and stem bark infusions or decoctions were revealed to be the most common folklore treatments for cholera in rural communities. The potential of medicinal plants as anti-Vibrio cholerae remedies based on their positive antibacterial assays, and mechanism of action is also presented. Finally, the development of innovative anti-Vibrio cholerae therapeutics based on natural leads and compounds and adapted for use in resource-constrained cholera-prone areas is viewed as a potential option, to complement cholera prevention and treatment, particularly in resource-limited endemic areas.

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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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