Christopher D Knapp, Kayla Horak, Nicholas S Roetker, Abigail Fink, Allan Gao, Kirsten L Johansen, Anne Murray, Allyson Hart
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引用次数: 0
摘要
背景：抑郁症在慢性肾病（CKD）（20-40%）和透析（30-50%）人群中的患病率很高。关于慢性肾病患者抑郁症状如何随时间变化的了解较少。方法：脑肾疾病（BRINK）队列研究的参与者每年完成一份抑郁症状问卷（PHQ-9）和血清肌酐检测。我们使用线性混合效应模型来检查PHQ-9评分随时间的变化，并比较不同eGFR损伤范围的参与者和eGFR正常的参与者之间的变化率。结果：基线时，147名参与者eGFR正常，424名参与者eGFR受损，无透析依赖，31%的参与者报告了抑郁症的诊断，平均基线PHQ-9评分为4.3。研究人员对参与者进行了长达5年的随访。调整抑郁相关因素后，在eGFR正常（60 ml/min/1.73m2）的参与者中，平均PHQ-9评分每年下降（提高）0.25分（95%置信区间[CI] 0.07, 0.42），在eGFR为45至59 ml/min/1.73m2、30至44 ml/min/1.73m2和有透析依赖的参与者中，分别下降0.35分（95% CI 0.14, 0.56）、0.30分（95% CI 0.13,0.46）和0.42分（95% CI 0.06, 0.77）。结论：随着时间的推移，参与者的平均PHQ-9评分基本稳定，我们观察到eGFR受损者和eGFR正常者的PHQ-9评分变化无差异。
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