Zoe E Neale, Kaitlin Bountress, Christina Sheerin, Stacey Saenz de Viteri, Shannon Cusack, David Chorlian, Peter B Barr, Isabelle Kaplan, Gayathri Pandey, Kristina A Osipenko, Vivia McCutcheon, Sally I-Chun Kuo, Megan E Cooke, Sarah J Brislin, Jessica E Salvatore, Chella Kamarajan, Bernice Porjesz, Ananda B Amstadter, Jacquelyn L Meyers
{"title":"儿童创伤与脑电图一致性、酒精相关结局和PTSD症状的发展轨迹有关。","authors":"Zoe E Neale, Kaitlin Bountress, Christina Sheerin, Stacey Saenz de Viteri, Shannon Cusack, David Chorlian, Peter B Barr, Isabelle Kaplan, Gayathri Pandey, Kristina A Osipenko, Vivia McCutcheon, Sally I-Chun Kuo, Megan E Cooke, Sarah J Brislin, Jessica E Salvatore, Chella Kamarajan, Bernice Porjesz, Ananda B Amstadter, Jacquelyn L Meyers","doi":"10.1017/S0033291724002599","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Associations between childhood trauma, neurodevelopment, alcohol use disorder (AUD), and posttraumatic stress disorder (PTSD) are understudied during adolescence.</p><p><strong>Methods: </strong>Using 1652 participants (51.75% female, baseline <i>M</i><sub>age</sub> = 14.3) from the Collaborative Study of the Genetics of Alcoholism, we employed latent growth curve models to (1) examine associations of childhood physical, sexual, and non-assaultive trauma (CPAT, CSAT, and CNAT) with repeated measures of alpha band EEG coherence (EEGc), and (2) assess whether EEGc trajectories were associated with AUD and PTSD symptoms. Sex-specific models accommodated sex differences in trauma exposure, AUD prevalence, and neural development.</p><p><strong>Results: </strong>In females, CSAT was associated with higher mean levels of EEGc in left frontocentral (LFC, ß = 0.13, <i>p</i> = 0.01) and interhemispheric prefrontal (PFI, ß = 0.16, <i>p</i> < 0.01) regions, but diminished growth in LFC (ß = -0.07, <i>p</i> = 0.02) and PFI (ß = -0.07, <i>p</i> = 0.02). In males, CPAT was associated with lower mean levels (ß = -0.17, <i>p</i> = 0.01) and increased growth (ß = 0.11, <i>p</i> = 0.01) of LFC EEGc. Slope of LFC EEGc was inversely associated with AUD symptoms in females (ß = -1.81, <i>p</i> = 0.01). Intercept of right frontocentral and PFI EEGc were associated with AUD symptoms in males, but in opposite directions. Significant associations between EEGc and PTSD symptoms were also observed in trauma-exposed individuals.</p><p><strong>Conclusions: </strong>Childhood assaultive trauma is associated with changes in frontal alpha EEGc and subsequent AUD and PTSD symptoms, though patterns differ by sex and trauma type. 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Sex-specific models accommodated sex differences in trauma exposure, AUD prevalence, and neural development.</p><p><strong>Results: </strong>In females, CSAT was associated with higher mean levels of EEGc in left frontocentral (LFC, ß = 0.13, <i>p</i> = 0.01) and interhemispheric prefrontal (PFI, ß = 0.16, <i>p</i> < 0.01) regions, but diminished growth in LFC (ß = -0.07, <i>p</i> = 0.02) and PFI (ß = -0.07, <i>p</i> = 0.02). In males, CPAT was associated with lower mean levels (ß = -0.17, <i>p</i> = 0.01) and increased growth (ß = 0.11, <i>p</i> = 0.01) of LFC EEGc. Slope of LFC EEGc was inversely associated with AUD symptoms in females (ß = -1.81, <i>p</i> = 0.01). Intercept of right frontocentral and PFI EEGc were associated with AUD symptoms in males, but in opposite directions. 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引用次数: 0
摘要
背景:儿童创伤、神经发育、酒精使用障碍(AUD)和创伤后应激障碍(PTSD)之间的关系在青春期尚未得到充分研究。方法:使用来自酒精中毒遗传学合作研究的1652名参与者(51.75%为女性,基线Mage = 14.3),我们采用潜在生长曲线模型(1)通过重复测量α带脑电图一致性(EEGc)来检查儿童身体、性和非攻击性创伤(CPAT、CSAT和CNAT)的关联,以及(2)评估EEGc轨迹是否与AUD和PTSD症状相关。性别特异性模型适应了创伤暴露、AUD患病率和神经发育方面的性别差异。结果:在女性中,CSAT与左额中央(LFC, ß = 0.13, p = 0.01)和半球间前额叶(PFI, ß = 0.16, p < 0.01)区域的eeg平均水平升高相关,但与LFC (ß = -0.07, p = 0.02)和PFI (ß = -0.07, p = 0.02)区域的eeg平均水平降低相关。在男性中,CPAT与LFC eeg平均水平较低(ß = -0.17, p = 0.01)和生长增加(ß = 0.11, p = 0.01)相关。LFC脑电图斜率与女性AUD症状呈负相关(ß = -1.81, p = 0.01)。男性右侧额中央和PFI脑电图截距与AUD症状相关,但方向相反。在创伤暴露个体中也观察到脑电图与创伤后应激障碍症状之间的显著关联。结论:儿童期侵犯性创伤与额叶α脑电图的改变以及随后的AUD和PTSD症状相关,尽管模式因性别和创伤类型而异。脑电图的发现可能为创伤后应激障碍和澳元的新兴治疗提供信息。
Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms.
Background: Associations between childhood trauma, neurodevelopment, alcohol use disorder (AUD), and posttraumatic stress disorder (PTSD) are understudied during adolescence.
Methods: Using 1652 participants (51.75% female, baseline Mage = 14.3) from the Collaborative Study of the Genetics of Alcoholism, we employed latent growth curve models to (1) examine associations of childhood physical, sexual, and non-assaultive trauma (CPAT, CSAT, and CNAT) with repeated measures of alpha band EEG coherence (EEGc), and (2) assess whether EEGc trajectories were associated with AUD and PTSD symptoms. Sex-specific models accommodated sex differences in trauma exposure, AUD prevalence, and neural development.
Results: In females, CSAT was associated with higher mean levels of EEGc in left frontocentral (LFC, ß = 0.13, p = 0.01) and interhemispheric prefrontal (PFI, ß = 0.16, p < 0.01) regions, but diminished growth in LFC (ß = -0.07, p = 0.02) and PFI (ß = -0.07, p = 0.02). In males, CPAT was associated with lower mean levels (ß = -0.17, p = 0.01) and increased growth (ß = 0.11, p = 0.01) of LFC EEGc. Slope of LFC EEGc was inversely associated with AUD symptoms in females (ß = -1.81, p = 0.01). Intercept of right frontocentral and PFI EEGc were associated with AUD symptoms in males, but in opposite directions. Significant associations between EEGc and PTSD symptoms were also observed in trauma-exposed individuals.
Conclusions: Childhood assaultive trauma is associated with changes in frontal alpha EEGc and subsequent AUD and PTSD symptoms, though patterns differ by sex and trauma type. EEGc findings may inform emerging treatments for PTSD and AUD.
期刊介绍:
Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.