代谢过程和细胞内信号通路诱导的上皮-间质转化(EMT)对实体瘤化疗耐药、转移和复发的影响。

IF 8.2 2区 生物学 Q1 CELL BIOLOGY Cell Communication and Signaling Pub Date : 2024-12-02 DOI:10.1186/s12964-024-01957-4
Mahsa Liaghat, Saeid Ferdousmakan, Seyedeh Haniyeh Mortazavi, Sheida Yahyazadeh, Asrin Irani, Sara Banihashemi, Fatemeh Sadat Seyedi Asl, Abdullatif Akbari, Farnoosh Farzam, Fatemeh Aziziyan, Maryam Bakhtiyari, Mohammad Javad Arghavani, Hamidreza Zalpoor, Mohsen Nabi-Afjadi
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引用次数: 0

摘要

复杂的细胞过程,被称为上皮-间质转化(EMT),显著影响实体瘤的发展。与EMT相关的细胞形状、代谢和基因表达的变化促进了肿瘤细胞的侵袭、转移、耐药性和复发。因此,更好地了解EMT背后的复杂过程及其在肿瘤生长中的作用可能会导致实体瘤治疗新方法的发展。本文就促进EMT和代谢的信号、导致EMT的细胞内信号通路以及EMT与癌细胞代谢的相互作用网络作一综述。此外,EMT在实体癌治疗耐药、复发和转移中的作用也被涵盖。最后,将讨论专注于细胞内信号网络和EMT带来的代谢改变的治疗方法。
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The impact of epithelial-mesenchymal transition (EMT) induced by metabolic processes and intracellular signaling pathways on chemo-resistance, metastasis, and recurrence in solid tumors.

The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors. This review article focuses on the signals that promote EMT and metabolism, the intracellular signaling pathways leading to EMT, and the network of interactions between EMT and cancer cell metabolism. Furthermore, the functions of EMT in treatment resistance, recurrence, and metastasis of solid cancers are covered. Lastly, treatment approaches that focus on intracellular signaling networks and metabolic alterations brought on by EMT will be discussed.

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来源期刊
CiteScore
11.00
自引率
0.00%
发文量
180
期刊介绍: Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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