子宫内膜异位症相关遗传因素及其在早产中的作用:一项双样本孟德尔随机研究

Christopher Flatley, Dana Kristjansson, Karin Ytterberg, Julius Juodakis, Pol Sole-Navais, Bo Jacobsson
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引用次数: 0

摘要

子宫内膜异位症影响全球10%的妇女,并与包括早产在内的不良妊娠结局有关。最近的流行病学和遗传学研究表明,子宫内膜异位症可能影响妊娠期和早产的可能性。本研究旨在利用最近全基因组关联研究(GWASs)的遗传数据,利用孟德尔随机化(MR)分析估计子宫内膜异位症对妊娠期和早产的直接遗传因果影响。
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Endometriosis-Related Genetic Factors and Their Role in Preterm Birth: A Two-Sample Mendelian Randomisation Study
Endometriosis affects 10% of women worldwide and is linked to adverse pregnancy outcomes, including preterm birth. Recent epidemiological and genetic studies indicate that endometriosis may influence gestational duration and the likelihood of preterm birth. This study aimed to estimate the direct genetic causal effects of endometriosis on gestational duration and preterm birth using Mendelian randomisation (MR) analysis, leveraging genetic data from recent genome-wide association studies (GWASs).
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