氨基比林呼气试验评价酒精患者肝功能:药物药代动力学和环境因素。

Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI:10.1300/J251v07n03_04

E A Lane

{"title":"氨基比林呼气试验评价酒精患者肝功能:药物药代动力学和环境因素。","authors":"E A Lane","doi":"10.1300/J251v07n03_04","DOIUrl":null,"url":null,"abstract":"Drug pharmacokinetics and environmental factors contribute to the selection of an ideal drug substrate for the determination of liver function via the carbon dioxide breath test. An ideal drug should be rapidly absorbed, and have an hepatic extraction ratio between 0.2 and 0.5. Its metabolism should not be induced by ethanol or be affected by cigarette smoking. The relative promise of caffeine and methacetin are compared to aminopyrine.","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"25-32"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_04","citationCount":"6","resultStr":"{\"title\":\"The aminopyrine breath test for the evaluation of liver function in alcoholic patients: drug pharmacokinetics and environmental factors.\",\"authors\":\"E A Lane\",\"doi\":\"10.1300/J251v07n03_04\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Drug pharmacokinetics and environmental factors contribute to the selection of an ideal drug substrate for the determination of liver function via the carbon dioxide breath test. An ideal drug should be rapidly absorbed, and have an hepatic extraction ratio between 0.2 and 0.5. Its metabolism should not be induced by ethanol or be affected by cigarette smoking. The relative promise of caffeine and methacetin are compared to aminopyrine.\",\"PeriodicalId\":77481,\"journal\":{\"name\":\"Advances in alcohol & substance abuse\",\"volume\":\"7 3-4\",\"pages\":\"25-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1300/J251v07n03_04\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in alcohol & substance abuse\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1300/J251v07n03_04\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in alcohol & substance abuse","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1300/J251v07n03_04","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 6

摘要

药物的药代动力学和环境因素有助于通过二氧化碳呼气试验确定肝功能的理想药物底物的选择。理想的药物应吸收迅速，肝提取比在0.2 ~ 0.5之间。其代谢不应由乙醇诱导或受吸烟影响。咖啡因和methacetin的相对前景与氨基比林进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The aminopyrine breath test for the evaluation of liver function in alcoholic patients: drug pharmacokinetics and environmental factors.

Drug pharmacokinetics and environmental factors contribute to the selection of an ideal drug substrate for the determination of liver function via the carbon dioxide breath test. An ideal drug should be rapidly absorbed, and have an hepatic extraction ratio between 0.2 and 0.5. Its metabolism should not be induced by ethanol or be affected by cigarette smoking. The relative promise of caffeine and methacetin are compared to aminopyrine.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advances in alcohol & substance abuse

自引率

0.00%

发文量

期刊最新文献

Controlled Opiate Use Addictive behaviors and benzodiazepines: 2. Are there differences between benzodiazepines in potential for physical dependence and abuse liability? Drug dependence: defining the issues. Benzodiazepines: reconsidered. Addiction potential of benzodiazepines and non-benzodiazepine anxiolytics.