罕见组织细胞肿瘤1例。

Surgical neurology international Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.25259/SNI_795_2024
Sabrina Maria Genovese, Jakov Tiefenbach, Ravi A Nunna, Andrew Youkilis
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引用次数: 0

摘要

背景:组织细胞肿瘤的定义是过多的组织细胞积聚在各种组织中,包括皮肤、骨骼、淋巴结和中枢神经系统。病例描述:一名76岁男性,表现为缓慢进行性双侧下肢无力(即右>左)一个月,伴T7以下左侧感觉下降。增强胸部磁共振(MR)成像显示在T5水平有一个硬膜内髓内结节,从C7延伸到T10。患者接受了T4-T6椎板切除术以完全切除病变。CD163和CD68的研究强调了一个小的纺锤形肿瘤,偶尔有增大的组织细胞,没有S100的共阳性。病理上,病变被认为是一个孤立的髓内胸椎LCH。结论:一名76岁男性表现为持续1个月的进行性麻痹,原因是mr增强记录的T5单发髓内T5胸椎LCH已成功切除。
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Rare histiocytic neoplasm: A case report.

Background: Histiocytic neoplasms are defined by too many histiocytes accumulating in various tissues, including the skin, bones, lymph nodes, and central nervous system. They are uncommon blood-related disorders that constitute <1% of cancers found in soft tissues and lymph nodes. Most referred to as Langerhans cell histiocytosis (LCH) or non-LCH, there are over 100 different sub-types that are divided into five groups. Here, a 76-year-old male presented with an intramedullary thoracic LCH.

Case description: A 76-year-old male presented with the month of slowly progressive bilateral lower extremity weakness (i.e., right > left) accompanied by decreased left-sided sensation below the T7 level. The enhanced thoracic magnetic resonance (MR) imaging documented an intradural intramedullary nodule at the T5 level with a syrinx extending from C7 to T10. The patient underwent a T4-T6 laminectomy for complete resection of the lesion. CD163 and CD68 studies highlighted a small, spindled-shaped tumor with occasionally enlarged histiocytes without co-positivity for S100. Pathologically, the lesion was considered an isolated intramedullary thoracic LCH.

Conclusion: A 76-year-old male presented with progressive paraparesis of 1 month's duration attributed to an enhanced MR-documented T5 single intramedullary T5 thoracic LCH that was successfully resected.

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