感染时肺部的炎症微环境控制着SARS-CoV-2复制的先天控制

IF 17.6 1区 医学 Q1 IMMUNOLOGY Science Immunology Pub Date : 2024-12-06 DOI:10.1126/sciimmunol.adp7951
Paul J. Baker, Andrea C. Bohrer, Ehydel Castro, Eduardo P. Amaral, Maryonne Snow-Smith, Flor Torres-Juárez, Sydnee T. Gould, Artur T. L. Queiroz, Eduardo R. Fukutani, Cassandra M. Jordan, Jaspal S. Khillan, Kyoungin Cho, Daniel L. Barber, Bruno B. Andrade, Reed F. Johnson, Kerry L. Hilligan, Katrin D. Mayer-Barber
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引用次数: 0

摘要

COVID-19的严重程度受多种因素影响;然而,目前尚不清楚暴露于SARS-CoV-2时肺部的炎症环境如何影响病毒复制的控制。在这里,我们证明了SARS-CoV-2感染前小鼠肺部的免疫事件影响病毒控制,并确定了限制病毒复制的先天免疫途径。肺部炎症刺激,包括解决的、先前的金黄色葡萄球菌或流感呼吸道感染、持续的肺结核分枝杆菌感染、卵清蛋白/铝诱导的哮喘,或气道给药TLR配体和重组细胞因子,都在肺部建立了抗病毒状态,限制了SARS-CoV-2的复制。除了抗病毒I型干扰素外,TNFα和IL-1也可能是肺部增强病毒控制的先决条件。我们的研究表明,SARS-CoV-2可能受益于免疫静止的肺微环境,并表明SARS-CoV-2暴露前肺部炎症的异质性可能导致疾病结局的变异性。
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The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Severity of COVID-19 is affected by multiple factors; however, it is not understood how the inflammatory milieu of the lung at the time of SARS-CoV-2 exposure affects the control of viral replication. Here, we demonstrate that immune events in the mouse lung closely preceding SARS-CoV-2 infection affect viral control and identify innate immune pathways that limit viral replication. Pulmonary inflammatory stimuli including resolved, antecedent respiratory infections with Staphylococcus aureus or influenza, ongoing pulmonary Mycobacterium tuberculosis infection, ovalbumin/alum-induced asthma, or airway administration of TLR ligands and recombinant cytokines all establish an antiviral state in the lung that restricts SARS-CoV-2 replication. In addition to antiviral type I interferons, TNFα and IL-1 potently precondition the lung for enhanced viral control. Our work shows that SARS-CoV-2 may benefit from an immunologically quiescent lung microenvironment and suggests that heterogeneity in pulmonary inflammation preceding SARS-CoV-2 exposure may contribute to variability in disease outcomes.
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来源期刊
Science Immunology
Science Immunology Immunology and Microbiology-Immunology
CiteScore
32.90
自引率
2.00%
发文量
183
期刊介绍: Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.
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