从紫荆中分离出两个新的倍半萜酚咖啡酸酯。Benth交货。及其α-葡萄糖苷酶抑制活性。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-04 DOI:10.1016/j.fitote.2024.106327

Xingping Zhang, Wenjie Ma, Kepu Huang, Congxi Gao, Xiaoxue Jiang, Mingming Li, Kou Wang

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引用次数: 0

摘要

从紫荆花茎叶中分离得到两个新的倍半萜酸酯，bausesquate A(1)和bausesquate B(2)。通过UV、IR、HR-ESI-MS、1D和2D NMR、ECD谱和DP4+概率分析对两个化合物的结构进行了确证。在体外，化合物1和2对α-葡萄糖苷酶的抑制作用优于阿卡波糖（IC50 = 280.50±6.27 μM）， IC50分别为1.81±0.12 μM和3.79±0.27 μM。此外，还进行了分子对接和分子动力学模拟，分析了潜在的结合位点。

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Two new sesquiterpenol caffeates from Bauhinia brychycarpa Wall. ex Benth. and their α-glucosidase inhibitory activity.

Two new sesquiterpenol caffeates, bausesquitate A (1) and bausesquitate B (2), were isolated from the stems and leaves of Bauhinia brychycarpa. Structures of two compounds were confirmed by UV, IR, HR-ESI-MS, 1D and 2D NMR, ECD spectra and DP4+ probability analysis. In vitro, compounds 1 and 2 showed better inhibitory effect on α-glucosidase than acarbose (IC₅₀ = 280.50 ± 6.27 μM) with the IC₅₀ values of 1.81 ± 0.12 μM and 3.79 ± 0.27 μM. Additionally, molecular docking and molecular dynamics simulation were performed to analyze the potential binding sites.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.