抗淀粉样蛋白药物治疗阿尔茨海默病:考虑抑郁症的作用。

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY Neurodegenerative Diseases Pub Date : 2024-12-06 DOI:10.1159/000541783
Beatriz Pozuelo Moyano, Leonardo Zullo, Olivier Rouaud, Pierre Vandel, Armin von Gunten, Gilles Allali
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引用次数: 0

摘要

抑郁症状是痴呆症中第二常见的神经精神症状(NPS),有令人信服的论点将抑郁与大脑中的淀粉样蛋白沉积联系起来。抗淀粉样蛋白治疗的临床试验主要集中在认知和功能下降方面:患有阿尔茨海默病(AD)和显著精神症状的参与者通常被排除在抗淀粉样蛋白治疗之外,抑郁症状的改善也不被认为是结果。这篇观点文章的目的是分析,鉴于抑郁症和AD之间已知的联系,抑郁症患者是否仍应排除在抗淀粉样蛋白治疗之外。考虑到它们的纳入情况,我们将分析哪些因素可能干扰抗淀粉样蛋白治疗的正常运作。
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来源期刊
Neurodegenerative Diseases
Neurodegenerative Diseases 医学-临床神经学
CiteScore
5.90
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: ''Neurodegenerative Diseases'' is a bimonthly, multidisciplinary journal for the publication of advances in the understanding of neurodegenerative diseases, including Alzheimer''s disease, Parkinson''s disease, amyotrophic lateral sclerosis, Huntington''s disease and related neurological and psychiatric disorders.
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