Tiyani C Mthombeni, Johanita R Burger, Martha S Lubbe, Marlene Julyan, Molebogeng R Lekalakala-Mokaba
{"title":"2014-2019年南非林波波省一家转诊医院血液感染患者ESKAPE病原体发病率和抗生素耐药性的横断面研究","authors":"Tiyani C Mthombeni, Johanita R Burger, Martha S Lubbe, Marlene Julyan, Molebogeng R Lekalakala-Mokaba","doi":"10.4102/ajlm.v13i1.2519","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is a paucity of research on the incidence and antimicrobial resistance (AMR) of <i>Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spp. (ESKAPE) pathogens in Africa because of the inadequate establishment of AMR surveillance systems.</p><p><strong>Objective: </strong>This study reports on the incidence and AMR of bloodstream ESKAPE pathogens at a referral hospital in northern South Africa.</p><p><strong>Methods: </strong>This retrospective descriptive study used routinely collected bloodstream isolates (pathogen identification and antimicrobial susceptibility testing performed using automated systems) from the South African National Health Laboratory Service, from January 2014 to December 2019. Resistant phenotypes analysed included methicillin-resistant <i>S. aureus</i> and carbapenem-resistant <i>A. baumannii</i>.</p><p><strong>Results: </strong>The ESKAPE pathogen incidence rate was stable from 2014 to 2019 (<i>p</i> = 0.133). The most isolated pathogens were <i>S. aureus</i> (268/746; 35.9%) and <i>A. baumannii</i> (200/746; 26.8%). <i>Staphylococcus aureus</i> increased from 39 isolates in 2014 to 75 in 2019 (<i>p</i> = 0.132). The incidence rate of <i>A. baumannii</i> increased from 11.9% (16/134) in 2015 to 37.8% (68/180) in 2019 (<i>p</i> = 0.009). Most isolates (417/746; 55.9%) were from the neonatal ward. Carbapenem-resistant <i>A. baumannii</i> increased from 68.8% (11/16) in 2014 to 75.0% (51/68) in 2019 (<i>p</i> = 0.009). Methicillin-resistant <i>S. aureus</i> decreased from 56.0% (14/25) in 2016 to 17.3% (13/75) in 2019 (<i>p</i> = 0.260).</p><p><strong>Conclusion: </strong>Routine data provide essential information on the incidence of ESKAPE pathogens and AMR phenotypes, serving as a basis for an antibiogram, a surveillance tool in antibiotic stewardship programmes.</p><p><strong>What this study adds: </strong>The study provided local information on the incidence and AMR pattern of ESKAPE pathogens, which is essential when developing empiric treatment protocols for appropriate antibiotic prescribing and infection prevention and control practices.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"13 1","pages":"2519"},"PeriodicalIF":1.0000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621878/pdf/","citationCount":"0","resultStr":"{\"title\":\"ESKAPE pathogen incidence and antibiotic resistance in patients with bloodstream infections at a referral hospital in Limpopo, South Africa, 2014-2019: A cross-sectional study.\",\"authors\":\"Tiyani C Mthombeni, Johanita R Burger, Martha S Lubbe, Marlene Julyan, Molebogeng R Lekalakala-Mokaba\",\"doi\":\"10.4102/ajlm.v13i1.2519\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is a paucity of research on the incidence and antimicrobial resistance (AMR) of <i>Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and <i>Enterobacter</i> spp. (ESKAPE) pathogens in Africa because of the inadequate establishment of AMR surveillance systems.</p><p><strong>Objective: </strong>This study reports on the incidence and AMR of bloodstream ESKAPE pathogens at a referral hospital in northern South Africa.</p><p><strong>Methods: </strong>This retrospective descriptive study used routinely collected bloodstream isolates (pathogen identification and antimicrobial susceptibility testing performed using automated systems) from the South African National Health Laboratory Service, from January 2014 to December 2019. Resistant phenotypes analysed included methicillin-resistant <i>S. aureus</i> and carbapenem-resistant <i>A. baumannii</i>.</p><p><strong>Results: </strong>The ESKAPE pathogen incidence rate was stable from 2014 to 2019 (<i>p</i> = 0.133). The most isolated pathogens were <i>S. aureus</i> (268/746; 35.9%) and <i>A. baumannii</i> (200/746; 26.8%). <i>Staphylococcus aureus</i> increased from 39 isolates in 2014 to 75 in 2019 (<i>p</i> = 0.132). The incidence rate of <i>A. baumannii</i> increased from 11.9% (16/134) in 2015 to 37.8% (68/180) in 2019 (<i>p</i> = 0.009). Most isolates (417/746; 55.9%) were from the neonatal ward. Carbapenem-resistant <i>A. baumannii</i> increased from 68.8% (11/16) in 2014 to 75.0% (51/68) in 2019 (<i>p</i> = 0.009). Methicillin-resistant <i>S. aureus</i> decreased from 56.0% (14/25) in 2016 to 17.3% (13/75) in 2019 (<i>p</i> = 0.260).</p><p><strong>Conclusion: </strong>Routine data provide essential information on the incidence of ESKAPE pathogens and AMR phenotypes, serving as a basis for an antibiogram, a surveillance tool in antibiotic stewardship programmes.</p><p><strong>What this study adds: </strong>The study provided local information on the incidence and AMR pattern of ESKAPE pathogens, which is essential when developing empiric treatment protocols for appropriate antibiotic prescribing and infection prevention and control practices.</p>\",\"PeriodicalId\":45412,\"journal\":{\"name\":\"African Journal of Laboratory Medicine\",\"volume\":\"13 1\",\"pages\":\"2519\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621878/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/ajlm.v13i1.2519\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/ajlm.v13i1.2519","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
ESKAPE pathogen incidence and antibiotic resistance in patients with bloodstream infections at a referral hospital in Limpopo, South Africa, 2014-2019: A cross-sectional study.
Background: There is a paucity of research on the incidence and antimicrobial resistance (AMR) of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens in Africa because of the inadequate establishment of AMR surveillance systems.
Objective: This study reports on the incidence and AMR of bloodstream ESKAPE pathogens at a referral hospital in northern South Africa.
Methods: This retrospective descriptive study used routinely collected bloodstream isolates (pathogen identification and antimicrobial susceptibility testing performed using automated systems) from the South African National Health Laboratory Service, from January 2014 to December 2019. Resistant phenotypes analysed included methicillin-resistant S. aureus and carbapenem-resistant A. baumannii.
Results: The ESKAPE pathogen incidence rate was stable from 2014 to 2019 (p = 0.133). The most isolated pathogens were S. aureus (268/746; 35.9%) and A. baumannii (200/746; 26.8%). Staphylococcus aureus increased from 39 isolates in 2014 to 75 in 2019 (p = 0.132). The incidence rate of A. baumannii increased from 11.9% (16/134) in 2015 to 37.8% (68/180) in 2019 (p = 0.009). Most isolates (417/746; 55.9%) were from the neonatal ward. Carbapenem-resistant A. baumannii increased from 68.8% (11/16) in 2014 to 75.0% (51/68) in 2019 (p = 0.009). Methicillin-resistant S. aureus decreased from 56.0% (14/25) in 2016 to 17.3% (13/75) in 2019 (p = 0.260).
Conclusion: Routine data provide essential information on the incidence of ESKAPE pathogens and AMR phenotypes, serving as a basis for an antibiogram, a surveillance tool in antibiotic stewardship programmes.
What this study adds: The study provided local information on the incidence and AMR pattern of ESKAPE pathogens, which is essential when developing empiric treatment protocols for appropriate antibiotic prescribing and infection prevention and control practices.
期刊介绍：
The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.
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