[晚期胃癌胃空肠分流术治疗幽门狭窄及术前化疗伴根治性主动脉旁淋巴结清扫1例]。

Q4 Medicine Japanese Journal of Cancer and Chemotherapy Pub Date : 2024-11-01
Ryosuke Mizuno, Sanae Nakajima
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引用次数: 0

摘要

患者为60多岁男性,主诉胃反流,诊断为晚期胃癌(tub1, por1)伴幽门狭窄。计算机断层扫描显示主动脉旁淋巴结增大(PALN, #16a2)。术前诊断cT4aN2M1(LYM), cStageⅣb。患者行腹腔镜胃空肠旁路手术治疗幽门梗阻,术前化疗S-1+L-OHP(SOX) 2疗程。原发肿瘤和周围淋巴结转移灶均明显缩小,PALN未进一步扩大。因此,患者符合手术条件。术中诊断PALN#16a2为转移阳性,并行远端胃切除术并根治性淋巴结清扫(#16a2+b1)。保留胃空肠旁路重建,病理诊断为ypT2N3(15/60)。出院后行S-1+DTX(DS)辅助化疗1年,1年6个月无复发。本研究表明,晚期胃癌伴幽门狭窄和PALN增大,在胃空肠造口搭桥手术后及时行术前化疗,可行根治性主动脉旁淋巴结清扫术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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[A Case of Advanced Gastric Cancer with Radical Para-Aortic Lymph Node Dissection Following Gastric-Jejunal Bypass for Pyloric Stenosis and Preoperative Chemotherapy].

The patient was a man in his 60s who complained of gastric reflux and was diagnosed with advanced gastric cancer (tub1, por1)involving pyloric stenosis. Computed tomography revealed an enlarged para-aortic lymph node(PALN, #16a2). His preoperative diagnosis was cT4aN2M1(LYM), cStage Ⅳb. The patient underwent laparoscopic gastric jejunal bypass surgery to treat the pyloric obstruction and was administered 2 courses of preoperative chemotherapy with S-1+L-OHP(SOX). Significant shrinkage was observed in both the primary tumor and surrounding lymph node metastases, and the PALN did not exhibit further enlargement. Therefore, the patient was eligible for surgery. Intraoperative diagnosis of PALN#16a2 was positive for metastasis, and distal gastrectomy with radical para-aorticlymph node dissection(#16a2+b1)was performed. The gastric jejunal bypass was preserved for reconstruction, and the pathological diagnosis was ypT2N3(15/60). Following discharge, adjuvant chemotherapy with S-1+DTX(DS)was performed for 1 year, and no recurrence has been observed for 1 year and 6 months. This study showed that advanced gastric cancer with pyloric stenosis and PALN enlargement can be treated with radical para-aortic lymph node dissection through prompt introduction of preoperative chemotherapy following gastric jejunostomy bypass surgery.

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