{"title":"不同来源的上呼吸道感染中头痛和面部疼痛患病率和表型的比较-一项横断面研究。","authors":"Marcin Straburzyński, Marta Waliszewska-Prosół","doi":"10.5603/pjnns.103063","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim of study: </strong>This study aimed to compare headache and facial pain prevalence and headache phenotype among people with common upper respiratory tract infections (URTIs).</p><p><strong>Clinical rationale for study: </strong>Headache is a common symptom in viral URTI, but its phenotyping has so far been limited to coronavirus disease 2019 (COVID-19) and influenza. Additionally, the prevalence of facial pain in URTIs has only rarely been discussed in scientific publications.</p><p><strong>Material and methods: </strong>Patients with acute URTI symptoms were evaluated for headache phenotype using a semi-structured questionnaire. Antigen swab tests were performed in all participants.</p><p><strong>Results: </strong>The analysis included 276 URTI/APVRS (acute post-viral rhinosinusitis) episodes in 223 patients (136 women, 60.1%) aged 18-73 [mean 41.3 / median (25th, 75th) 40 / standard deviation 15.1]. Participants were diagnosed with: COVID-19 - 107/276 (38.8%); 'common cold' - 103/276 (37.3%); influenza - 36/276 (13.0%); or APVRS - 30/276 (10.9%). Headache was present in 183/276 (66.3%) and URTIs and facial pain in 107/276 (38.8%). Predictors of headache in URTIs included sinonasal symptoms (odds ratio (OR) 10.70, p < 0.001) and fever (OR 2.9, p = 0.004). Headache more often (p = 0.030) had a migraine-like phenotype in COVID-19 (27.4% (20/73) vs. 9.1% (10/110) and tension-type headache (TTH)-like phenotype in 'common cold' (75.4%, 49/64 vs. 61.3%, 73/119). Previous COVID-19 immunisation (vaccination or infection) was associated (p = 0.004) with a lower prevalence of migraine-like headache [6.3% (1/16) vs. 32.8% (19/58)].</p><p><strong>Conclusions and clinical implications: </strong>Headache and facial pain are prevalent during URTIs, and are associated with general and sinonasal immune response rather than virus type. Headache phenotype may depend on the causative microorganism, but it can evolve in response to previous immunisation. Our study supports vaccination against COVID-19, as people with prior immunisation are probably less likely to experience migraine-like headache.</p>","PeriodicalId":19132,"journal":{"name":"Neurologia i neurochirurgia polska","volume":" ","pages":"593-599"},"PeriodicalIF":2.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of headache and facial pain prevalence and phenotype in upper respiratory tract infections of differing origins - a cross-sectional study.\",\"authors\":\"Marcin Straburzyński, Marta Waliszewska-Prosół\",\"doi\":\"10.5603/pjnns.103063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim of study: </strong>This study aimed to compare headache and facial pain prevalence and headache phenotype among people with common upper respiratory tract infections (URTIs).</p><p><strong>Clinical rationale for study: </strong>Headache is a common symptom in viral URTI, but its phenotyping has so far been limited to coronavirus disease 2019 (COVID-19) and influenza. Additionally, the prevalence of facial pain in URTIs has only rarely been discussed in scientific publications.</p><p><strong>Material and methods: </strong>Patients with acute URTI symptoms were evaluated for headache phenotype using a semi-structured questionnaire. Antigen swab tests were performed in all participants.</p><p><strong>Results: </strong>The analysis included 276 URTI/APVRS (acute post-viral rhinosinusitis) episodes in 223 patients (136 women, 60.1%) aged 18-73 [mean 41.3 / median (25th, 75th) 40 / standard deviation 15.1]. Participants were diagnosed with: COVID-19 - 107/276 (38.8%); 'common cold' - 103/276 (37.3%); influenza - 36/276 (13.0%); or APVRS - 30/276 (10.9%). Headache was present in 183/276 (66.3%) and URTIs and facial pain in 107/276 (38.8%). Predictors of headache in URTIs included sinonasal symptoms (odds ratio (OR) 10.70, p < 0.001) and fever (OR 2.9, p = 0.004). Headache more often (p = 0.030) had a migraine-like phenotype in COVID-19 (27.4% (20/73) vs. 9.1% (10/110) and tension-type headache (TTH)-like phenotype in 'common cold' (75.4%, 49/64 vs. 61.3%, 73/119). Previous COVID-19 immunisation (vaccination or infection) was associated (p = 0.004) with a lower prevalence of migraine-like headache [6.3% (1/16) vs. 32.8% (19/58)].</p><p><strong>Conclusions and clinical implications: </strong>Headache and facial pain are prevalent during URTIs, and are associated with general and sinonasal immune response rather than virus type. Headache phenotype may depend on the causative microorganism, but it can evolve in response to previous immunisation. 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引用次数: 0
摘要
研究目的：本研究旨在比较常见上呼吸道感染（URTIs）患者头痛和面部疼痛的患病率和头痛表型。临床研究理由：头痛是病毒性尿路感染的常见症状，但其表型迄今仅限于2019冠状病毒病（COVID-19）和流感。此外，在科学出版物中很少讨论尿路感染中面部疼痛的患病率。材料和方法：采用半结构化问卷对急性尿路感染症状患者的头痛表型进行评估。对所有参与者进行抗原拭子试验。结果：分析包括223例18-73岁患者（136名女性，60.1%）276次URTI/APVRS（急性病毒后鼻窦炎）发作[平均41.3 /中位数（25、75）40 /标准差15.1]。参与者被诊断为：COVID-19 - 107/276 (38.8%)；“普通感冒”——103/276 (37.3%)；流感——36/276 (13.0%)；或APVRS - 30/276（10.9%）。183/276例出现头痛（66.3%），107/276例出现尿路感染和面部疼痛（38.8%）。尿路感染患者头痛的预测因素包括鼻窦症状（比值比（OR） 10.70, p < 0.001）和发烧（比值比（OR） 2.9, p = 0.004）。在COVID-19中，头痛更常具有偏头痛样表型(27.4%（20/73）对9.1%(10/110)，在“普通感冒”中，头痛更常具有紧张性头痛（TTH）样表型（75.4%，49/64对61.3%,73/119）。既往COVID-19免疫接种（疫苗接种或感染）与较低的偏头痛样头痛患病率相关（p = 0.004）[6.3%（1/16）对32.8%(19/58)]。结论和临床意义：头痛和面部疼痛在尿路感染中普遍存在，并且与全身和鼻腔免疫反应有关，而与病毒类型无关。头痛的表型可能取决于致病微生物，但它可以在对先前免疫的反应中进化。我们的研究支持针对COVID-19的疫苗接种，因为事先接种过疫苗的人可能不太可能出现类似偏头痛的头痛。
Comparison of headache and facial pain prevalence and phenotype in upper respiratory tract infections of differing origins - a cross-sectional study.
Aim of study: This study aimed to compare headache and facial pain prevalence and headache phenotype among people with common upper respiratory tract infections (URTIs).
Clinical rationale for study: Headache is a common symptom in viral URTI, but its phenotyping has so far been limited to coronavirus disease 2019 (COVID-19) and influenza. Additionally, the prevalence of facial pain in URTIs has only rarely been discussed in scientific publications.
Material and methods: Patients with acute URTI symptoms were evaluated for headache phenotype using a semi-structured questionnaire. Antigen swab tests were performed in all participants.
Results: The analysis included 276 URTI/APVRS (acute post-viral rhinosinusitis) episodes in 223 patients (136 women, 60.1%) aged 18-73 [mean 41.3 / median (25th, 75th) 40 / standard deviation 15.1]. Participants were diagnosed with: COVID-19 - 107/276 (38.8%); 'common cold' - 103/276 (37.3%); influenza - 36/276 (13.0%); or APVRS - 30/276 (10.9%). Headache was present in 183/276 (66.3%) and URTIs and facial pain in 107/276 (38.8%). Predictors of headache in URTIs included sinonasal symptoms (odds ratio (OR) 10.70, p < 0.001) and fever (OR 2.9, p = 0.004). Headache more often (p = 0.030) had a migraine-like phenotype in COVID-19 (27.4% (20/73) vs. 9.1% (10/110) and tension-type headache (TTH)-like phenotype in 'common cold' (75.4%, 49/64 vs. 61.3%, 73/119). Previous COVID-19 immunisation (vaccination or infection) was associated (p = 0.004) with a lower prevalence of migraine-like headache [6.3% (1/16) vs. 32.8% (19/58)].
Conclusions and clinical implications: Headache and facial pain are prevalent during URTIs, and are associated with general and sinonasal immune response rather than virus type. Headache phenotype may depend on the causative microorganism, but it can evolve in response to previous immunisation. Our study supports vaccination against COVID-19, as people with prior immunisation are probably less likely to experience migraine-like headache.
期刊介绍：
Polish Journal of Neurology and Neurosurgery is an official journal of the Polish Society of Neurology and the Polish Society of Neurosurgeons, aimed at publishing high quality articles within the field of clinical neurology and neurosurgery, as well as related subspecialties. For more than a century, the journal has been providing its authors and readers with the opportunity to report, discuss, and share the issues important for every-day practice and research advances in the fields related to neurology and neurosurgery.
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