消极情绪与炎症性皮肤病的因果关系:一项双向孟德尔随机研究。

IF 3.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Postgraduate Medical Journal Pub Date : 2024-12-09 DOI:10.1093/postmj/qgae173
Keyi Zhang, Mingwei Zeng, Li Lei, Chuhan Fu, Jiangfeng Huang, Shu Zhou, Yaqing Wen, Jinhua Huang, Jing Chen, Qinghai Zeng
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引用次数: 0

摘要

目的:观察性研究表明情绪与炎症性皮肤病之间存在潜在联系。然而,关于不同类型的情绪与炎症性皮肤病之间的因果关系的研究还很缺乏。本研究旨在通过孟德尔随机化(MR)分析,探讨消极情绪与炎症性皮肤病之间的因果关系。方法:从MRC-IEU联盟进行的全基因组关联研究(GWAS)中获得7种负性情绪的汇总数据。7种炎症性皮肤病包括白癜风、牛皮癣、系统性红斑狼疮、湿疹、特应性皮炎、痤疮和酒渣鼻。MR分析主要采用逆方差加权法(IVW),并辅以MR- egger等3种MR方法。结果:IVW方法显示,内疚情绪有可能增加银屑病的风险(OR = 1.02, 95% CI: 1.00 ~ 1.05, P = 0.019),而担忧/焦虑情绪对湿疹有潜在的风险影响(OR = 1.07, 95% CI: 1.00 ~ 1.13, P = 0.042)。银屑病可增加痛苦感(OR = 1.41, 95% CI: 1.18-1.68, P = 0.0001)、忧虑/焦虑感(OR = 1.26, 95% CI: 1.02-1.57, P = 0.033)、紧张感(OR = 1.25, 95% CI: 1.05-1.49, P = 0.012)和孤独感/孤立感(OR = 1.19, 95% CI: 1.04-1.36, P = 0.009)的发生。湿疹可能导致担心/焦虑情绪的发生率增加(OR = 1.038, 95% CI: 1.007-1.070, P = 0.014)。结论:本MR研究揭示了担忧/焦虑情绪与湿疹之间的双向因果关系。研究还发现,负罪感可能会增加患牛皮癣的风险,牛皮癣患者可能会经历更多的痛苦、担忧/焦虑感、紧张感和孤独/孤立感。
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The causal relationship between negative emotions and inflammatory dermatoses: a bidirectional Mendelian randomization study.

Purpose: Observational studies have suggested a potential link between emotions and inflammatory dermatoses. However, research on the causal relationship between different types of emotions and inflammatory dermatoses is lacking. This study is aimed to investigate the causal relationship between negative emotions and inflammatory dermatoses through Mendelian randomization (MR) analysis.

Methods: Summary data of seven negative emotions were obtained from a genome-wide association study (GWAS) conducted by the MRC-IEU consortium. Seven inflammatory dermatoses including vitiligo, psoriasis, systemic lupus erythematosus, eczema, atopic dermatitis, acne, and rosacea were obtained from published GWAS. The MR analysis primarily employed the Inverse variance weighted (IVW) method, and supplemented by MR-Egger and other three MR methods.

Results: The IVW method revealed that guilty feelings have potential to increase the risk of psoriasis (OR = 1.02, 95% CI: 1.00-1.05, P = 0.019), while worrier/anxious feelings have a potential risk effect on eczema (OR = 1.07, 95% CI: 1.00-1.13, P = 0.042). Psoriasis could increase the occurrence of miserableness (OR = 1.41, 95% CI: 1.18-1.68, P = 0.0001), worrier/anxious feelings (OR = 1.26, 95% CI: 1.02-1.57, P = 0.033), nervous feelings (OR = 1.25, 95% CI: 1.05-1.49, P = 0.012), and loneliness/isolation (OR = 1.19, 95% CI: 1.04-1.36, P = 0.009). Eczema might cause an increased incidence of worrier/anxious feelings (OR = 1.038, 95% CI: 1.007-1.070, P = 0.014).

Conclusion: This MR study revealed bidirectional causality between worrier/anxious feelings and eczema. It also found that guilty feelings may elevate the risk of psoriasis, and individuals with psoriasis may experience increased rates of miserableness, worrier/anxious feelings, nervous feelings, and loneliness/isolation.

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来源期刊
Postgraduate Medical Journal
Postgraduate Medical Journal 医学-医学:内科
CiteScore
8.50
自引率
2.00%
发文量
131
审稿时长
2.5 months
期刊介绍: Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.
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