精神分裂症不同阶段的脑结构损伤网络。

IF 5.9 2区 医学 Q1 PSYCHIATRY Psychological Medicine Pub Date : 2024-12-11 DOI:10.1017/S0033291724003088
Ruoxuan Xu, Xiaohan Zhang, Shanlei Zhou, Lixin Guo, Fan Mo, Haining Ma, Jiajia Zhu, Yinfeng Qian
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引用次数: 0

摘要

背景:神经影像学研究已经记录了精神分裂症不同阶段的脑结构变化,包括临床高危(cHR)、遗传高危(gHR)、首发精神分裂症(FES)和慢性精神分裂症(ChS)。越来越多的人意识到,与疾病相关的神经病理过程不能映射到特定的大脑区域,但可以映射到特定的大脑网络。我们试图研究精神分裂症不同阶段的大脑结构损伤网络。方法:我们最初确定了523名cHR、855名gHR、2162名FES和2640名ChS个体相对于6963名健康对照者的灰质改变。通过将新的功能连接网络映射应用于大规模的发现和验证静息状态功能磁共振成像数据集,我们将这些受影响的大脑位置映射到四个特定的网络。结果:cHR和gHR的脑结构损伤网络空间分布有限且不重叠,前者主要累及额顶叶网络,后者主要累及皮层下网络,表明cHR和gHR的神经病理机制不同。相比之下,FES和ChS的脑结构损伤网络表现为广泛的大脑区域的相似模式,主要涉及躯体运动、腹侧注意和皮层下网络,这表明随着疾病的发作,出现了更突出的脑结构异常,随着时间的推移,这些异常具有类似特征的稳定性。结论:我们的研究结果可能不仅从网络角度提供了精神分裂症神经病理学的精细图像,而且可能有助于为不同阶段的精神分裂症个体提供更有针对性和有效的干预策略。
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Brain structural damage networks at different stages of schizophrenia.

Background: Neuroimaging studies have documented brain structural changes in schizophrenia at different stages of the illness, including clinical high-risk (cHR), genetic high-risk (gHR), first-episode schizophrenia (FES), and chronic schizophrenia (ChS). There is growing awareness that neuropathological processes associated with a disease fail to map to a specific brain region but do map to a specific brain network. We sought to investigate brain structural damage networks across different stages of schizophrenia.

Methods: We initially identified gray matter alterations in 523 cHR, 855 gHR, 2162 FES, and 2640 ChS individuals relative to 6963 healthy controls. By applying novel functional connectivity network mapping to large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we mapped these affected brain locations to four specific networks.

Results: Brain structural damage networks of cHR and gHR had limited and non-overlapping spatial distributions, with the former mainly involving the frontoparietal network and the latter principally implicating the subcortical network, indicative of distinct neuropathological mechanisms underlying cHR and gHR. By contrast, brain structural damage networks of FES and ChS manifested as similar patterns of widespread brain areas predominantly involving the somatomotor, ventral attention, and subcortical networks, suggesting an emergence of more prominent brain structural abnormalities with illness onset that have trait-like stability over time.

Conclusions: Our findings may not only provide a refined picture of schizophrenia neuropathology from a network perspective, but also potentially contribute to more targeted and effective intervention strategies for individuals at different schizophrenia stages.

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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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