Marta Di Forti, Benjamin W Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B M Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-Zimmerman, Tim Meynen, Diego Quattrone, Robin M Murray
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To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.</p><p><strong>Aims: </strong>Examine outcome data from the first 46 individuals to complete the CCP's intervention.</p><p><strong>Method: </strong>The sample (<i>N</i> = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. 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引用次数: 0
摘要
背景：大麻使用严重影响精神病患者的预后，但缺乏治疗方法。为了解决这一问题，2019年建立了国家卫生服务体系（NHS）大麻精神病诊所（CCP），以支持患有精神病的成年人减少和/或停止使用大麻。目的：检查前46名完成CCP干预的个体的结果数据。方法：样本（N = 46）由2020年1月至2023年2月期间由南伦敦和莫兹利NHS基金会信托基金（简称CCP）护理的精神病成年人（年龄≥18岁）组成，他们于2023年9月完成干预。在CCP干预（一对一会议和同伴小组出席）之前（T0）和之后（T1）收集临床和功能测量。主要结果是大麻使用障碍识别测试修订（CUDIT-R）评分和大麻使用模式的变化。次要结果包括妄想、偏执、抑郁、焦虑和功能的T0-T1变化。结果：在T0和T1之间观察到CUDIT-R平均评分降低（平均差值= 17.10,95% CI = 15.54-18.67）， 73.91%的参与者实现了戒断，26.09%的参与者减少了使用频率和效力。所有临床和功能结果均有显著改善，在T1时有90.70%的人在工作或接受教育，而在T0时为8.70%。CUDIT-R评分的差异解释了我们二级测量中34 - 64%的差异。结论：CCP干预是一种可行的策略，可以支持停止/减少大麻使用，改善精神障碍患者的临床和功能结局。
A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders.
Background: Cannabis use severely affects the outcome of people with psychotic disorders, yet there is a lack of treatments. To address this, in 2019 the National Health Service (NHS) Cannabis Clinic for Psychosis (CCP) was developed to support adults suffering from psychosis to reduce and/or stop their cannabis use.
Aims: Examine outcome data from the first 46 individuals to complete the CCP's intervention.
Method: The sample (N = 46) consisted of adults (aged ≥ 18) with psychosis under the care of the South London and Maudsley NHS Foundation Trust, referred to the CCP between January 2020 and February 2023, who completed their intervention by September 2023. Clinical and functional measures were collected before (T0) and after (T1) the CCP intervention (one-to-one sessions and peer group attendance). Primary outcomes were changes in the Cannabis Use Disorders Identification Test-Revised (CUDIT-R) score and pattern of cannabis use. Secondary outcomes included T0-T1 changes in measures of delusions, paranoia, depression, anxiety and functioning.
Results: A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54-18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. The variance in CUDIT-R scores explained between 34 and 64% of the variance in our secondary measures.
Conclusions: The CCP intervention is a feasible strategy to support cannabis use cessation/reduction and improve clinical and functional outcomes of people with psychotic disorders.
期刊介绍：
Announcing the launch of BJPsych Open, an exciting new open access online journal for the publication of all methodologically sound research in all fields of psychiatry and disciplines related to mental health. BJPsych Open will maintain the highest scientific, peer review, and ethical standards of the BJPsych, ensure rapid publication for authors whilst sharing research with no cost to the reader in the spirit of maximising dissemination and public engagement. Cascade submission from BJPsych to BJPsych Open is a new option for authors whose first priority is rapid online publication with the prestigious BJPsych brand. Authors will also retain copyright to their works under a creative commons license.
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