A Rare Case of NK Large Granular Lymphocytic Proliferative Disorder.

Background: Chronic NK-cell lymphoproliferative disease (CLPD-NK) is a very rare lymphoproliferative disorder in which patients often have an elevated lymphocyte population without clinical symptoms.

Methods: In this particular case, a middle-aged woman presented with a consistent elevation in her lymphocyte proportion over a span of four consecutive years during physical examinations, without manifesting any other notable clinical symptoms. The underlying cause of this phenomenon was ultimately identified through a comprehensive evaluation that encompassed peripheral blood cell morphology analysis, lymphocyte subset profiling, and peripheral blood immunophenotyping. These diagnostic tools collectively provided crucial insights into the nature of the disease.

Results: The patient was finally diagnosed with CLPD-NK. As part of her management plan, the patient was advised to undergo regular annual physical examinations to monitor the progression of the disease and any potential changes in her health status.

Conclusions: CLPD-NK is a chronic progressive lymphoproliferative disease, which can be followed up regularly if there are no clinical symptoms. Severe reductions in neutrophils, red blood cells, and platelets or other complications may require chemotherapy or bone marrow transplantation.