自身免疫性风湿病矽肺患者队列中分枝杆菌感染的风险

IF 2.9 4区医学 Q2 RESPIRATORY SYSTEM Jornal Brasileiro De Pneumologia Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI:10.36416/1806-3756/e20240265

Rafael Futoshi Mizutani, Ubiratan Paula Santos, Roberta Karla Barbosa Sales, Emily Figueiredo Neves Yuki, Elisa Maria Siqueira Lombardi, Lavinia Clara Del Roio, Mario Terra-Filho

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引用次数: 0

摘要

目的：探讨矽肺合并系统性自身免疫性风湿病（ARD）患者分枝杆菌感染的发生率。方法：对1999年1月至2023年12月矽肺患者进行回顾性队列研究。我们比较了合并和不合并ARD的矽肺患者中结核和非结核分枝杆菌病（NTM）的发病率。我们还比较了整个队列的结核病发病率与巴西一般人口估计值。结果：本研究纳入369例矽肺患者，其中35例（9.5%）患有ARD。患有ARD并不影响分枝杆菌疾病的累积发病率。与巴西成年男性人群相比，该队列中患结核病的风险更高(年龄调整后发病率比= 20.46；95% ci 14.89-28.13)。结论：在这组矽肺病患者中，ARD与分枝杆菌疾病的发病率无关。

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Risk of mycobacterial infections in a cohort of silicosis patients with autoimmune rheumatic diseases.

Objective: To evaluate the incidence rates of mycobacterial infections in silicosis patients with systemic autoimmune rheumatic disease (ARD).

Methods: This was a retrospective cohort of silicosis patients between January of 1999 and December of 2023. We compared the incidence of tuberculosis and nontuberculous mycobacterial disease (NTM) in patients with silicosis with and without ARD. We also compared the tuberculosis incidence in the overall cohort with general Brazilian population estimates.

Results: The study comprised 369 silicosis patients, of whom 35 (9.5%) had ARD. Having ARD did not affect the cumulative incidence of mycobacterial diseases. The risk of tuberculosis was higher in the cohort when compared with that in the adult Brazilian male population (age-adjusted incidence rate ratio = 20.46; 95% CI 14.89-28.13).

Conclusions: In this cohort of patients with silicosis, ARD was not associated with the incidence of mycobacterial diseases.

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来源期刊

Jornal Brasileiro De Pneumologia RESPIRATORY SYSTEM-

CiteScore

3.50

自引率

14.80%

发文量

118

审稿时长

20 weeks

期刊介绍： The Brazilian Journal of Pulmonology publishes scientific articles that contribute to the improvement of knowledge in the field of the lung diseases and related areas.