发育和细胞命运分析支持小鼠肾脏皮质收集系统的出生后起源。

IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY Journal of The American Society of Nephrology Pub Date : 2024-12-11 DOI:10.1681/ASN.0000000579
Riana K Parvez, Réka L Csipán, Jing Liu, Ara Gevorgyan, Elisabeth A Rutledge, Jinjin Guo, Doh Kyung Kim, Andrew P McMahon
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引用次数: 0

摘要

背景:哺乳动物肾脏的结构和功能沿径向轴组织,以皮质髓质组织和收集系统的区域模式为重点。在出生后第3天,通过控制输尿管皮层分支尖端的Wnt11+祖细胞的生长、分支和承诺,树突收集上皮形成。方法:采用原位杂交和免疫荧光技术对收集管细胞类型的关键标记物在小鼠胚胎和出生后肾脏中的分布进行检测。为了研究输尿管祖细胞在特定时间对成年小鼠肾脏细胞多样性和空间组织的贡献,我们对胚胎和出生后早期小鼠肾脏中的Wnt11+细胞进行了遗传谱系追踪。结果:细胞命运分析显示大部分皮质集管网络是在出生后建立的。此外,输尿管祖细胞衍生的收集系统和结构上同源的肾元祖细胞衍生的连接小管的上皮重组、区域分化和关键细胞类型的功能成熟直到出生后2周左右才完成,形成成人样的收集上皮。结论:这些研究强调了相对未被充分研究的早期产后时期对哺乳动物肾脏功能发育的重要性。
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Developmental and Cell Fate Analyses Support a Postnatal Origin for the Cortical Collecting System in the Mouse Kidney.
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来源期刊
Journal of The American Society of Nephrology
Journal of The American Society of Nephrology 医学-泌尿学与肾脏学
CiteScore
22.40
自引率
2.90%
发文量
492
审稿时长
3-8 weeks
期刊介绍: The Journal of the American Society of Nephrology (JASN) stands as the preeminent kidney journal globally, offering an exceptional synthesis of cutting-edge basic research, clinical epidemiology, meta-analysis, and relevant editorial content. Representing a comprehensive resource, JASN encompasses clinical research, editorials distilling key findings, perspectives, and timely reviews. Editorials are skillfully crafted to elucidate the essential insights of the parent article, while JASN actively encourages the submission of Letters to the Editor discussing recently published articles. The reviews featured in JASN are consistently erudite and comprehensive, providing thorough coverage of respective fields. Since its inception in July 1990, JASN has been a monthly publication. JASN publishes original research reports and editorial content across a spectrum of basic and clinical science relevant to the broad discipline of nephrology. Topics covered include renal cell biology, developmental biology of the kidney, genetics of kidney disease, cell and transport physiology, hemodynamics and vascular regulation, mechanisms of blood pressure regulation, renal immunology, kidney pathology, pathophysiology of kidney diseases, nephrolithiasis, clinical nephrology (including dialysis and transplantation), and hypertension. Furthermore, articles addressing healthcare policy and care delivery issues relevant to nephrology are warmly welcomed.
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