乳头浸润性鳞状细胞癌1例并文献复习。

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2025-03-01 Epub Date: 2024-11-21 DOI:10.1097/DAD.0000000000002880
Scott Potter, Evin Gulbahce, Jane Porretta, Lesley Lomo, Keith Duffy, Nicole Winkler, Joshua Coleman, Jolanta Jedrzkiewicz
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引用次数: 0

摘要

摘要:本病例为73岁女性,右乳出血,随后影像学检查发现皮肤增厚。在临床上,这些发现引起了人们对佩吉特病的关注。皮肤穿刺活检显示高级别浸润性癌伴鳞状特征。考虑到该患者有浸润性导管癌和同一乳房放射治疗的病史,化脓性癌是一种鉴别诊断。随后的中央乳房肿瘤切除术证实了乳头浸润性鳞状细胞癌的诊断,发生在Bowen病的背景下,作为前体病变。值得注意的是,在背景乳腺组织或传统浸润性导管癌成分中没有导管原位癌的证据。乳头的原位和侵袭性鳞状细胞癌都很少被报道。这个病例强调了考虑这种罕见诊断的重要性,特别是在有乳腺癌病史的患者中。
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Invasive Squamous Cell Carcinoma of the Nipple: Case Report With Literature Review.

Abstract: In this unusual case, a 73-year-old woman presented with bloody discharge from her right breast and skin thickening was observed on subsequent imaging. Clinically, the findings raised concern for Paget disease. A skin punch biopsy was performed, revealing a high-grade infiltrating carcinoma with squamous features. Metaplastic carcinoma was a differential diagnosis, given that this patient had a history of invasive ductal carcinoma and radiation treatment in the same breast. A subsequent central lumpectomy confirmed the diagnosis of invasive squamous cell carcinoma of the nipple, occurring in the context of Bowen disease as a precursor lesion. Notably, there was no evidence of ductal carcinoma in situ in the background breast tissue or conventional invasive ductal carcinoma component. Both in situ and invasive forms of squamous cell carcinomas have been rarely reported in the nipple. This case highlights the importance of considering such a rare diagnosis, especially in patients with a history of breast cancer.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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