IF 6.8 1区 医学 Q1 CHEMISTRY, MEDICINAL Journal of Medicinal Chemistry Pub Date : 2024-12-12 DOI:10.1021/acs.jmedchem.4c02359
Kirsten Dahl, Kirsten Raun, Jakob Lerche Hansen, Christian Poulsen, Charlotta D. de la Cour, Trine Ryberg Clausen, Ann Maria Kruse Hansen, Linu M. John, Annette Plesner, Gao Sun, Morten Schlein, Rikke Bjerring Skyggebjerg, Thomas Kruse
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引用次数: 0

摘要

更正:第 11691 页的以下段落现为第 11693 页表 12 的脚注。"数据为平均值 ± SEM,大鼠单次 sc 注射 30 nmol/kg 试验物质后,食物摄入量相对于载体的百分比。卡格瑞林肽的数据先前已公布7 ,在 0-24 小时和 24-48 小时期间,食物摄入量分别减少 85% 和 84%。SEM 为平均值的标准误差"。更正:以下段落曾作为第 11692 页表 9 的脚注,现已移至第 11691 页。"从体外数据(表 10 和表 11)可以看出,有几种肽(10、14、15、16、17、18、20 和 21)具有选择性。从 ThT 试验(表 9 和佐证资料)来看,只有三种 AMYR 选择性肽(14、16 和 21)能够抵抗物理压力超过 40 小时。肽 6 和具有中性/高 pI 的肽 11-21 被选为进一步的体内评估对象,以评估它们在一次给药后降低大鼠食物摄入量的能力,并进一步了解肽在体内的作用持续时间(表 11)"。本文尚未被其他出版物引用。
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Correction to “NN1213 – A Potent, Long-Acting, and Selective Analog of Human Amylin”
Correction: The following paragraph previously on page 11691 is now the footnote for Table 12 on page 11693. “Data are mean ± SEM measured as percent food intake relative to vehicle in rats after a single sc injection of 30 nmol/kg of the test substance. Data for cagrilintide have been published previously7 giving rise to 85% and 84% reduction of food intake in the periods from 0–24 h and 24–48 h, respectively. SEM is the standard error of the mean.” Correction: The following paragraph was previously included as the footnotes for Table 9 on page 11692 and has been moved to page 11691. “From the in vitro data (Tables 10 and 11), it was apparent that selectivity was achieved for several peptides (10, 14, 15, 16, 17, 18, 20, and 21). From the ThT assay (Table 9 and Supporting Information), only three of the AMYR selective peptides (14, 16, and 21) were able to resist physical stress for more than 40 h. Two peptides (15 and 21) had a selectivity ratio above 30. Peptide 6 and peptides 1121 with neutral/high pI were chosen for further evaluation in vivo to evaluate their ability to reduce food intake in rats after a single administration and to have increased insights into the duration of effects from the peptides in vivo (Table 11).” This article has not yet been cited by other publications.
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来源期刊
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry 医学-医药化学
CiteScore
4.00
自引率
11.00%
发文量
804
审稿时长
1.9 months
期刊介绍: The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents. The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.
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