{"title":"来自天然灵芝子实体的高修饰羊角甾烷三萜类化合物。","authors":"Somporn Palasarn , Wilunda Choowong , Natthawut Wiriyathanawudhiwong , Rattaket Choeyklin , Masahiko Isaka","doi":"10.1016/j.fitote.2024.106336","DOIUrl":null,"url":null,"abstract":"<div><div>Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G–K (<strong>1</strong>–<strong>5</strong>), ganoboninone I (<strong>6</strong>), ganoderlactone G (<strong>7</strong>), and (24<em>E</em>)-3,11-dioxolanosta-8,24-dien-26-oic acid (<strong>8</strong>), were isolated from natural fruiting bodies of <em>Ganoderma</em> cf. <em>hochiminhense</em>. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (<strong>1</strong>), H (<strong>2</strong>), and J (<strong>4</strong>) exhibited antimalarial activity against <em>Plasmodium falciparum</em> K1 (multidrug-resistant strain) with IC<sub>50</sub> values of 17, 16, and 5.1 μM, respectively.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"180 ","pages":"Article 106336"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly modified lanostane triterpenoids from natural fruiting bodies of Ganoderma cf. hochiminhense\",\"authors\":\"Somporn Palasarn , Wilunda Choowong , Natthawut Wiriyathanawudhiwong , Rattaket Choeyklin , Masahiko Isaka\",\"doi\":\"10.1016/j.fitote.2024.106336\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G–K (<strong>1</strong>–<strong>5</strong>), ganoboninone I (<strong>6</strong>), ganoderlactone G (<strong>7</strong>), and (24<em>E</em>)-3,11-dioxolanosta-8,24-dien-26-oic acid (<strong>8</strong>), were isolated from natural fruiting bodies of <em>Ganoderma</em> cf. <em>hochiminhense</em>. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (<strong>1</strong>), H (<strong>2</strong>), and J (<strong>4</strong>) exhibited antimalarial activity against <em>Plasmodium falciparum</em> K1 (multidrug-resistant strain) with IC<sub>50</sub> values of 17, 16, and 5.1 μM, respectively.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"180 \",\"pages\":\"Article 106336\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24005197\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24005197","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Highly modified lanostane triterpenoids from natural fruiting bodies of Ganoderma cf. hochiminhense
Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G–K (1–5), ganoboninone I (6), ganoderlactone G (7), and (24E)-3,11-dioxolanosta-8,24-dien-26-oic acid (8), were isolated from natural fruiting bodies of Ganoderma cf. hochiminhense. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (1), H (2), and J (4) exhibited antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 17, 16, and 5.1 μM, respectively.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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