急性髓性白血病中髓源性抑制样细胞的预后价值:免疫分型和临床相关性的启示。

IF 3.3 4区 医学 Q3 IMMUNOLOGY Immunologic Research Pub Date : 2024-12-14 DOI:10.1007/s12026-024-09558-6
Alexia N Sant'Ana, Camila K Dias, Vitória B S Nunes, Mariela G Farias, Ana P Alegretti, Pâmela Portela, Ebellins T Calvache, Maria F Meirelles, Liane E Daudt, Mariana B Michalowski, Alessandra A Paz, Fabrício Figueiró
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引用次数: 0

摘要

髓源性抑制细胞(MDSCs)是一种异质性细胞群,可同时作用于先天性免疫和适应性免疫,促进肿瘤中的免疫逃逸并导致癌症进展。尽管缺乏对 MDSC(尤其是多形核(PMN-MDSC)亚群)进行免疫分型的明确标记,但这些细胞似乎在急性髓性白血病(AML)患者的预后中起着至关重要的作用。此外,MDSCs 的成熟阶段仍是一个争论的话题,而且在 AML 范畴内,MDSCs 的成熟阶段在很大程度上是未知的。在本研究中,我们对急性髓细胞白血病患者诊断时获得的流式细胞术免疫分型数据进行了回顾性分析。我们探讨了中性粒细胞成熟阶段的富集、PMN-MDSC样细胞和单核细胞MDSC样群(M-MDSC样)的频率以及MDSC样细胞与T淋巴细胞的比率与相关预后指标的相关性。我们的研究结果显示,CD45+CD33-lowHLA-DR-CD36+ PMN-MDSC样细胞和成熟的CD13+CD11b+CD10+中性粒细胞与急性髓细胞白血病患者的不良生存率相关。此外,PMN-MDSC 样细胞及其与 T 淋巴细胞的比例在有不良风险分层的患者中升高。同样,在FLT3-ITD突变携带者中,M-MDSC样细胞也会增加。值得注意的是,我们观察到 CD36 与急性髓细胞性白血病相关的确凿证据,最近 CD36 已成为 PMN-MDSCs 的潜在标志物。我们的研究强调了急性髓细胞性白血病中 MDSC 样亚群增加与不良预后因素相关的重要发现。
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Prognostic value of myeloid-derived suppressor-like cells in acute myeloid leukemia: insights from immunophenotyping and clinical correlations.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population that acts on both innate and adaptive immunity, fostering immune escape in tumors and contributing to cancer progression. Despite the lack of definitive markers for immunophenotyping MDSCs, particularly the polymorphonuclear (PMN-MDSC) subset, these cells seem to play a crucial role in acute myeloid leukemia (AML) patients' prognosis. Additionally, the maturation stage of MDSCs remains a subject of debate and is largely unknown within the AML context. In this study, we conducted a retrospective analysis of flow cytometry immunophenotyping data obtained at the diagnosis of AML patients. We explored how the enrichment of neutrophil maturation stages, the frequency of PMN-MDSC-like cells and monocytic MDSC-like population (M-MDSC-like), and the ratios of MDSC-like cells to T lymphocytes correlate with relevant prognostic indicators. Our findings revealed that CD45+CD33lowHLA-DR-CD36+ PMN-MDSC-like cells and mature CD13+CD11b+CD10+ neutrophils correlate poor survival in AML patients. Furthermore, PMN-MDSC-like cells, and their ratio to T lymphocytes, are elevated in patients with adverse-risk stratification. Similarly, the M-MDSC-like population is increased in FLT3-ITD mutation carrier patients. Notably, we observed confirmational evidence of CD36 relevance in the AML context, which has emerged recently as a potential marker for PMN-MDSCs. Our study highlights significant findings associating increased MDSC-like subsets and poor prognostic factors in AML.

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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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