脑脊液中YKL-40水平可作为脑卒中患者术后细菌性脑膜炎的诊断生物标志物。

IF 2.5 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinical biochemistry Pub Date : 2025-01-01 DOI:10.1016/j.clinbiochem.2024.110864
Jingtao Wang, Xiaofeng Wang, Hongwei Cheng, Lei Ye
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引用次数: 0

摘要

导言:以前的研究表明,YKL-40 可作为感染性疾病和不同类型中风的生物标记物。方法:共招募了 110 名接受神经外科治疗的脑卒中患者。其中 36 例根据细菌培养/革兰氏染色结果或脑脊液(CSF)特征被诊断为 PNBM。采用单变量和逻辑回归模型对 YKL-40 和其他具有潜在诊断作用的 PNBM 生物标志物的 CSF 水平进行了统计分析。为研究诊断效率,还进行了接收者操作特征(ROC)分析:单变量分析显示,PNBM 组和非 PNBM 组之间的葡萄糖、总蛋白、白细胞、多形性细胞和 YKL-40 的 CSF 水平以及 CSF 与血糖比值存在显著差异。逻辑回归分析显示,脑脊液中的葡萄糖(p = 0.026)、总蛋白(p = 0.028)和 YKL-40 (p = 0.006)水平可能对 PNBM 有独立的诊断作用。在这三种生物标志物中,CSF-血糖(接收者操作特征曲线下面积 [AUC] 0.9208)和 YKL-40(AUC 0.9587)具有很强的诊断效用:结论:脑脊液中的 YKL-40、葡萄糖和总蛋白水平在脑卒中患者 PNBM 的诊断中发挥着独立作用。
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YKL-40 levels in cerebrospinal fluid serve as a diagnostic biomarker for post-neurosurgical bacterial meningitis in patients with stroke

Introduction

Previous studies have reported that YKL-40 can serve as a biomarker of infectious diseases and different stroke types. However, evidence supporting its role in diagnosing post-neurosurgical bacterial meningitis (PNBM) remains lacking.

Methods

A total of 110 patients with stroke who underwent neurosurgical treatment were recruited. Among these, 36 were diagnosed with PNBM based on the results of bacterial culture/Gram staining or cerebrospinal fluid (CSF) characteristics. CSF levels of YKL-40 and other biomarkers with potential diagnostic utility for PNBM were statistically analysed using univariate and logistic regression models. Receiver operating characteristic (ROC) analysis was performed to investigate diagnostic efficiency.

Results

According to univariate analysis, CSF levels of glucose, total protein, white blood cells, polymorphocytes, and YKL-40, as well as the CSF-to-blood glucose ratio, were significantly different between the PNBM and non-PNBM groups. Logistic regression analysis revealed that glucose (p = 0.026), total protein (p = 0.028), and YKL-40 (p = 0.006) levels in the CSF may have independent diagnostic utility for PNBM. Among the three biomarkers, CSF-to-blood glucose (area under the receiver operating characteristic curve [AUC] 0.9208) and YKL-40 (AUC 0.9587) demonstrated strong diagnostic utility.

Conclusion

CSF levels of YKL-40, glucose, and total protein played independent roles in the diagnosis of PNBM in patients with stroke.
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来源期刊
Clinical biochemistry
Clinical biochemistry 医学-医学实验技术
CiteScore
5.10
自引率
0.00%
发文量
151
审稿时长
25 days
期刊介绍: Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.
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