混合血液净化联合乌司他丁治疗严重败血症对 APACHE II 评分及 miR-146a 和 miR-155 水平的影响

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-12-08 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S491193
Kai Wang, Jihong Zhu, Weibo Gao, Wei Guo, Yang Guo
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引用次数: 0

摘要

背景:严重败血症是由感染引起的全身炎症反应综合征,急性生理评估和慢性健康评估II(APACHE II)评分系统被广泛用于评估严重患者的严重程度。混合血液净化治疗(HBPT)和乌利那他汀(UTI)在多种炎症性疾病中显示出良好的疗效,而 miR-146a 和 miR-155 被发现与炎症反应密切相关。本研究旨在探讨 HBPT 联合UTI 治疗严重败血症患者的效果,尤其是对 APACHE II 评分、miR-146a 和 miR-155 水平的影响:我们对我院 2020 年 1 月至 2022 年 6 月收治的重症脓毒症患者的临床资料进行了回顾性分析。根据治疗记录将患者分为 HBPT 组和 HBPT+UTI 组。分析并比较两组患者治疗前后的APACHE II评分、miR-146a水平、miR-155水平、炎症因子和康复状况:共有150人参与分析,其中HBPT+UTI组77人,HBPT组73人。治疗后,APACHE II 评分、miR-146a、miR-155 和炎症因子水平均明显低于治疗前。此外,HBPT+UTI 组的数值明显低于 HBPT 组(均 P < 0.05)。HBPT+UTI组的血清淀粉酶恢复时间、腹痛消失时间和住院时间均明显短于HBPT组(均P<0.05):结论:UTI治疗联合HBPT可改善重症脓毒症患者的APACHE II评分,减轻炎症反应,明显改善短期预后。
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The Effect of Hybrid Blood Purification Combined with Ulinastatin for the Treatment of Severe Sepsis on APACHE II Score and Levels of miR-146a and miR-155.

Background: Severe sepsis is a systemic inflammatory response syndrome caused by infection, and the Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) scoring system is widely used to assess the severity of severe patients. Hybrid blood purification treatment (HBPT) and ulinastatin (UTI) have shown good efficacy in a variety of inflammatory diseases, and miR-146a and miR-155 were found to be closely related to inflammatory reaction. The purpose of this study was to investigate the effect of HBPT combined with UTI in the treatment of patients with severe sepsis, especially the effects on APACHE II score and miR-146a and miR-155 levels.

Methods: We carried out a retrospective analysis of clinical data with severe sepsis admitted to our hospital from January 2020 to June 2022. The patients were divided into an HBPT or HBPT+UTI group according to the treatment records. The APACHE II score, miR-146a level, miR-155 level, inflammatory factors, and rehabilitation status of both groups were analyzed and compared before and after treatment.

Results: A total of 150 were included in the analysis, there were 77 participants in HBPT+UTI and 73 in HBPT group. After treatment, the APACHE II score and levels of miR-146a, miR-155, and inflammatory factors were significantly lower than that before treatment. Furthermore, the HBPT+UTI group showed significantly lower values than the HBPT group (all P < 0.05). The recovery time of serum amylase, the disappearance time of abdominal pain, and the length of hospitalization in the HBPT+UTI group were significantly shorter than those in the HBPT group (all P < 0.05).

Conclusion: UTI treatment combined with the administration of HBPT could improve the APACHE II score, alleviate the inflammatory reaction, and significantly improve the short-term prognosis of the patients with severe sepsis.

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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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