{"title":"肠道菌群、代谢物和糖尿病肾病之间的因果关系：来自两样本孟德尔随机化分析的见解。","authors":"Xixi Song, Jingqiu Cui, Shiwei Li, Bo Huang","doi":"10.2147/IJNRD.S489074","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong> Previous studies have established a correlation between gut microbiota, metabolites, and diabetic nephropathy (DN). However, the inherent limitations of observational studies, including reverse causality and confounding factors, made this relationship uncertain.</p><p><strong>Methods: </strong>In this study, we compiled summary statistics from a genome-wide association study (GWAS) conducted on gut microbiota, metabolites, and DN. We employed a two-sample Mendelian randomization (MR) approach, utilizing inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods.</p><p><strong>Results: </strong> We detected the protective nature of genetically predicted representatives from the family Bacteroidaceae (OR: 0.716, 95% CI: 0.516-0.995, <i>p</i> = 0.046), family Victivallaceae (OR: 0.871, 95% CI: 0.772-0.982, <i>p</i> = 0.026), genus Bacteroides (OR: 0.716, 95% CI: 0.516-0.995, <i>p</i> = 0.046), genus Coprococcus 2 (OR: 0.745, 95% CI: 0.576-0.963, <i>p</i> = 0.025), and genus Lactococcus (OR: 0.851, 95% CI: 0.730-0.992, <i>p</i> = 0.039) against the development of DN. Conversely, we identified a positive correlation between the incidence of DN and entities, such as Phylum Bacteroidetes (OR: 1.427, 95% CI: 1.085-1.875, <i>p</i> = 0.011), class Bacteroidia (OR: 1.304, 95% CI: 1.036-1.641,<i>p</i> = 0.024), order Bacteroidales (OR: 1.304, 95% CI: 1.035-1.641, <i>p</i> = 0.028), genus Catenibacterium (OR: 1.312, 95% CI: 1.079-1.594, <i>p</i> = 0.006), genus Lachnoclostridium (OR: 1.434, 95% CI: 1.129-1.821, <i>p</i> = 0.003), and genus Parasutterella (OR: 1.270, 95% CI: 1.070-1.510, <i>p</i> = 0.006). In our analysis, none of the gut metabolites demonstrated a causal relationship with DN.</p><p><strong>Conclusion: </strong> Our results substantiated the potential causal association between specific gut microbiota and DN. Therefore, our study offers novel insight into the mechanisms underlying DN. This finding provides a theoretical foundation for the future development of targeted strategies for the prevention and treatment of DN.</p>","PeriodicalId":14181,"journal":{"name":"International Journal of Nephrology and Renovascular Disease","volume":"17 ","pages":"319-332"},"PeriodicalIF":2.1000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645948/pdf/","citationCount":"0","resultStr":"{\"title\":\"Causal Relationships Between Gut Microbiota, Metabolites, and Diabetic Nephropathy: Insights from a Two-Sample Mendelian Randomization Analysis.\",\"authors\":\"Xixi Song, Jingqiu Cui, Shiwei Li, Bo Huang\",\"doi\":\"10.2147/IJNRD.S489074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong> Previous studies have established a correlation between gut microbiota, metabolites, and diabetic nephropathy (DN). However, the inherent limitations of observational studies, including reverse causality and confounding factors, made this relationship uncertain.</p><p><strong>Methods: </strong>In this study, we compiled summary statistics from a genome-wide association study (GWAS) conducted on gut microbiota, metabolites, and DN. We employed a two-sample Mendelian randomization (MR) approach, utilizing inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods.</p><p><strong>Results: </strong> We detected the protective nature of genetically predicted representatives from the family Bacteroidaceae (OR: 0.716, 95% CI: 0.516-0.995, <i>p</i> = 0.046), family Victivallaceae (OR: 0.871, 95% CI: 0.772-0.982, <i>p</i> = 0.026), genus Bacteroides (OR: 0.716, 95% CI: 0.516-0.995, <i>p</i> = 0.046), genus Coprococcus 2 (OR: 0.745, 95% CI: 0.576-0.963, <i>p</i> = 0.025), and genus Lactococcus (OR: 0.851, 95% CI: 0.730-0.992, <i>p</i> = 0.039) against the development of DN. Conversely, we identified a positive correlation between the incidence of DN and entities, such as Phylum Bacteroidetes (OR: 1.427, 95% CI: 1.085-1.875, <i>p</i> = 0.011), class Bacteroidia (OR: 1.304, 95% CI: 1.036-1.641,<i>p</i> = 0.024), order Bacteroidales (OR: 1.304, 95% CI: 1.035-1.641, <i>p</i> = 0.028), genus Catenibacterium (OR: 1.312, 95% CI: 1.079-1.594, <i>p</i> = 0.006), genus Lachnoclostridium (OR: 1.434, 95% CI: 1.129-1.821, <i>p</i> = 0.003), and genus Parasutterella (OR: 1.270, 95% CI: 1.070-1.510, <i>p</i> = 0.006). In our analysis, none of the gut metabolites demonstrated a causal relationship with DN.</p><p><strong>Conclusion: </strong> Our results substantiated the potential causal association between specific gut microbiota and DN. Therefore, our study offers novel insight into the mechanisms underlying DN. This finding provides a theoretical foundation for the future development of targeted strategies for the prevention and treatment of DN.</p>\",\"PeriodicalId\":14181,\"journal\":{\"name\":\"International Journal of Nephrology and Renovascular Disease\",\"volume\":\"17 \",\"pages\":\"319-332\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-12-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645948/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Nephrology and Renovascular Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/IJNRD.S489074\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Nephrology and Renovascular Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/IJNRD.S489074","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Causal Relationships Between Gut Microbiota, Metabolites, and Diabetic Nephropathy: Insights from a Two-Sample Mendelian Randomization Analysis.
Background: Previous studies have established a correlation between gut microbiota, metabolites, and diabetic nephropathy (DN). However, the inherent limitations of observational studies, including reverse causality and confounding factors, made this relationship uncertain.
Methods: In this study, we compiled summary statistics from a genome-wide association study (GWAS) conducted on gut microbiota, metabolites, and DN. We employed a two-sample Mendelian randomization (MR) approach, utilizing inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods.
Results: We detected the protective nature of genetically predicted representatives from the family Bacteroidaceae (OR: 0.716, 95% CI: 0.516-0.995, p = 0.046), family Victivallaceae (OR: 0.871, 95% CI: 0.772-0.982, p = 0.026), genus Bacteroides (OR: 0.716, 95% CI: 0.516-0.995, p = 0.046), genus Coprococcus 2 (OR: 0.745, 95% CI: 0.576-0.963, p = 0.025), and genus Lactococcus (OR: 0.851, 95% CI: 0.730-0.992, p = 0.039) against the development of DN. Conversely, we identified a positive correlation between the incidence of DN and entities, such as Phylum Bacteroidetes (OR: 1.427, 95% CI: 1.085-1.875, p = 0.011), class Bacteroidia (OR: 1.304, 95% CI: 1.036-1.641,p = 0.024), order Bacteroidales (OR: 1.304, 95% CI: 1.035-1.641, p = 0.028), genus Catenibacterium (OR: 1.312, 95% CI: 1.079-1.594, p = 0.006), genus Lachnoclostridium (OR: 1.434, 95% CI: 1.129-1.821, p = 0.003), and genus Parasutterella (OR: 1.270, 95% CI: 1.070-1.510, p = 0.006). In our analysis, none of the gut metabolites demonstrated a causal relationship with DN.
Conclusion: Our results substantiated the potential causal association between specific gut microbiota and DN. Therefore, our study offers novel insight into the mechanisms underlying DN. This finding provides a theoretical foundation for the future development of targeted strategies for the prevention and treatment of DN.
期刊介绍：
International Journal of Nephrology and Renovascular Disease is an international, peer-reviewed, open-access journal focusing on the pathophysiology of the kidney and vascular supply. Epidemiology, screening, diagnosis, and treatment interventions are covered as well as basic science, biochemical and immunological studies. In particular, emphasis will be given to: -Chronic kidney disease- Complications of renovascular disease- Imaging techniques- Renal hypertension- Renal cancer- Treatment including pharmacological and transplantation- Dialysis and treatment of complications of dialysis and renal disease- Quality of Life- Patient satisfaction and preference- Health economic evaluations. The journal welcomes submitted papers covering original research, basic science, clinical studies, reviews & evaluations, guidelines, expert opinion and commentary, case reports and extended reports. The main focus of the journal will be to publish research and clinical results in humans but preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies and interventions.
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