特应性皮炎与炎症性肠病风险之间的关联：一项纵向研究的meta分析

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY JGH Open Pub Date : 2024-12-12 DOI:10.1002/jgh3.70077

Pengfei Yu, Li Lin, Kaiyuan Xue, Jingwen Yang, Shanshan Wang, Yuepeng An, Suqing Yang

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摘要

目的：本综述旨在通过分析纵向研究的数据来调查特应性皮炎（AD）是否会增加炎症性肠病（IBD）的风险。方法：纳入了评估AD与IBD、克罗恩病（CD）或溃疡性结肠炎（UC）风险之间关系的队列研究和病例对照研究。文献检索在PubMed， CENTRAL, Embase， Scopus和Web of Science数据库中进行，截止到2024年4月15日。结果：共纳入8项回顾性队列研究，包括61 190 816名参与者。荟萃分析显示，AD显著增加IBD的风险（OR: 1.37, 95% CI: 1.31-1.43），无统计学异质性。进一步的汇总分析显示，AD是CD （OR: 1.51, 95% CI: 1.31-1.76）和UC （OR: 1.33, 95% CI: 1.13-1.56）的重要危险因素，且研究间异质性较高（I 2分别= 83%和89%）。敏感性分析证实了结果的稳健性。结论：AD与IBD的风险增加相关，显著提高CD和UC的风险。

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The Association Between Atopic Dermatitis and Inflammatory Bowel Disease Risk: A Meta-Analysis of Longitudinal Studies

Aims

This review aimed to investigate whether atopic dermatitis (AD) increases the risk of inflammatory bowel disease (IBD) by analyzing data from longitudinal studies.

Methods

Cohort and case–control studies evaluating the association between AD and the risk of IBD, Crohn's disease (CD), or ulcerative colitis (UC) were included. Literature searches were conducted in PubMed, CENTRAL, Embase, Scopus, and Web of Science databases up to April 15, 2024.

Results

A total of eight retrospective cohort studies comprising 61 190 816 participants were included. Meta-analysis revealed that AD significantly increased the risk of IBD (OR: 1.37, 95% CI: 1.31–1.43) without statistical heterogeneity. Further pooled analysis showed that AD was a significant risk factor for CD (OR: 1.51, 95% CI: 1.31–1.76) and UC (OR: 1.33, 95% CI: 1.13–1.56), with high inter-study heterogeneity (I² = 83% and 89%, respectively). Sensitivity analyses confirmed the robustness of the results.