针对衰竭心脏中巨噬细胞与成纤维细胞的相互作用

IF 41.7 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Nature Reviews Cardiology Pub Date : 2024-12-16 DOI:10.1038/s41569-024-01112-z

Nikolaos G. Frangogiannis

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引用次数: 0

摘要

巨噬细胞-成纤维细胞相互作用在心脏纤维化中起核心作用。在左心室压力过载的反应中，CCR2+心脏巨噬细胞获得成纤维表型，分泌IL-1β，并通过转录因子MEOX1促进FAP+ POSTN+成纤维细胞亚群的激活。巨噬细胞衍生的成纤维细胞激活因子（如IL-1β）、生长因子和基质细胞蛋白参与心力衰竭的发病机制。

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Targeting macrophage–fibroblast interactions in the failing heart

Macrophage–fibroblast interactions have a central role in cardiac fibrosis. In response to left ventricular pressure overload, CCR2+ cardiac macrophages acquire a fibrogenic phenotype, secreting IL-1β and promoting the activation of a FAP+ POSTN+ fibroblast subpopulation through the transcription factor MEOX1. Macrophage-derived fibroblast-activating cytokines (such as IL-1β), growth factors and matricellular proteins contribute to the pathogenesis of heart failure.

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.