微量营养素和胃肠胰腺神经内分泌肿瘤的风险:孟德尔随机研究。

IF 2.9 Q3 NUTRITION & DIETETICS Clinical nutrition ESPEN Pub Date : 2024-12-14 DOI:10.1016/j.clnesp.2024.11.003
Ruilin Wang, Yuxiu Ma, Xuelin Liu, Chunyan Dang, Hongling Li
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引用次数: 0

摘要

背景:胃肠胰神经内分泌肿瘤(GEP-NETs)是一种异质性的罕见肿瘤。微量营养素对GEP-NETs的影响已经在观察性研究中进行了探讨,但结果不一致。我们进行了一项双样本孟德尔随机化(TSMR)研究,以调查微量营养素是否影响GEP-NETs的风险。方法:从全基因组关联研究(GWAS)中获得15种微量营养素(维生素A、叶酸、维生素B6、维生素B12、维生素C、维生素D、维生素E、类胡萝卜素、钙、铜、铁、镁、硒、锌和钾)和GEP-NET结果的汇总统计数据。应用五种磁共振分析方法来探讨潜在的因果关系。结果:基因预测较高的血清铁浓度(OR=5.71, 95%CI=1.02 ~ 31.97, P=0.047)和血清钙浓度(OR=4.90, 95%CI=1.29 ~ 18.63, P=0.019)与结直肠神经内分泌肿瘤风险增加相关。然而,没有证据表明其余13种微量营养素与结直肠神经内分泌肿瘤之间存在关联,也没有证据表明这15种微量营养素中的任何一种会影响胃、小肠和胰腺神经内分泌肿瘤的风险。结论:我们的MR分析提示血清铁和钙浓度可能影响结直肠神经内分泌肿瘤的风险,但需要进一步的研究来证实这些发现。
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WITHDRAWN: Micronutrients and risk of gastroenteropancreatic neuroendocrine tumours: a Mendelian randomisation study

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies/article-withdrawal

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来源期刊
Clinical nutrition ESPEN
Clinical nutrition ESPEN NUTRITION & DIETETICS-
CiteScore
4.90
自引率
3.30%
发文量
512
期刊介绍: Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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