{"title":"二氯甲烷、硝酸盐和硫血红蛋白诱导物质对碳氧血红蛋白检测的影响综述。","authors":"Jialin Wu, Yujing Luan, Qingxia Zhang, Fanglin Wang, Yulan Rao","doi":"10.1093/jat/bkae096","DOIUrl":null,"url":null,"abstract":"<p><p>Carbon monoxide (CO) is a common gaseous toxin that causes severe poisoning symptoms. Accurate detection of the formation of carboxyhemoglobin (COHb) in the blood is very important for the identification of CO poisoning. In this review, the effects of exogenous toxins, including dichloromethane (DCM), nitrite and hydrogen sulfide, on the determination of COHb by spectrophotometry were summarized by comparing epidemiological data, case studies and analytical methods. The mechanism of the effects of these exogenous poisons on COHb detection is described, and the extent of their influence on the clinical diagnosis and forensic identification of CO poisoning is discussed. We suggest that emergency medicine and forensic science practices need to improve the understanding of these toxins, and optimize clinical diagnosis and evaluation strategies to address the effects of toxins on the determination of COHb.</p>","PeriodicalId":14905,"journal":{"name":"Journal of analytical toxicology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of Dichloromethane, Nitrate, and Sulfhemoglobin-Induced Substances on Carboxyhemoglobin Detection: A Comprehensive Review.\",\"authors\":\"Jialin Wu, Yujing Luan, Qingxia Zhang, Fanglin Wang, Yulan Rao\",\"doi\":\"10.1093/jat/bkae096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Carbon monoxide (CO) is a common gaseous toxin that causes severe poisoning symptoms. Accurate detection of the formation of carboxyhemoglobin (COHb) in the blood is very important for the identification of CO poisoning. In this review, the effects of exogenous toxins, including dichloromethane (DCM), nitrite and hydrogen sulfide, on the determination of COHb by spectrophotometry were summarized by comparing epidemiological data, case studies and analytical methods. The mechanism of the effects of these exogenous poisons on COHb detection is described, and the extent of their influence on the clinical diagnosis and forensic identification of CO poisoning is discussed. We suggest that emergency medicine and forensic science practices need to improve the understanding of these toxins, and optimize clinical diagnosis and evaluation strategies to address the effects of toxins on the determination of COHb.</p>\",\"PeriodicalId\":14905,\"journal\":{\"name\":\"Journal of analytical toxicology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of analytical toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/jat/bkae096\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of analytical toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jat/bkae096","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
摘要
一氧化碳（CO）是一种常见的气体毒素，可导致严重的中毒症状。准确检测血液中碳氧血红蛋白（COHb）的形成对于识别一氧化碳中毒非常重要。本综述通过比较流行病学数据、案例研究和分析方法，总结了二氯甲烷（DCM）、亚硝酸盐和硫化氢等外源性毒素对分光光度法测定 COHb 的影响。阐述了这些外源性毒物对 COHb 检测的影响机制，并讨论了它们对 CO 中毒的临床诊断和法医鉴定的影响程度。我们建议，急诊医学和法医学实践需要提高对这些毒素的认识，并优化临床诊断和评估策略，以应对毒素对 COHb 检测的影响。
Effects of Dichloromethane, Nitrate, and Sulfhemoglobin-Induced Substances on Carboxyhemoglobin Detection: A Comprehensive Review.
Carbon monoxide (CO) is a common gaseous toxin that causes severe poisoning symptoms. Accurate detection of the formation of carboxyhemoglobin (COHb) in the blood is very important for the identification of CO poisoning. In this review, the effects of exogenous toxins, including dichloromethane (DCM), nitrite and hydrogen sulfide, on the determination of COHb by spectrophotometry were summarized by comparing epidemiological data, case studies and analytical methods. The mechanism of the effects of these exogenous poisons on COHb detection is described, and the extent of their influence on the clinical diagnosis and forensic identification of CO poisoning is discussed. We suggest that emergency medicine and forensic science practices need to improve the understanding of these toxins, and optimize clinical diagnosis and evaluation strategies to address the effects of toxins on the determination of COHb.
期刊介绍：
The Journal of Analytical Toxicology (JAT) is an international toxicology journal devoted to the timely dissemination of scientific communications concerning potentially toxic substances and drug identification, isolation, and quantitation.
Since its inception in 1977, the Journal of Analytical Toxicology has striven to present state-of-the-art techniques used in toxicology labs. The peer-review process provided by the distinguished members of the Editorial Advisory Board ensures the high-quality and integrity of articles published in the Journal of Analytical Toxicology. Timely presentation of the latest toxicology developments is ensured through Technical Notes, Case Reports, and Letters to the Editor.
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