对ASRM和SART委员会关于非整倍体（PGT-A）植入前基因检测使用的意见的补充意见。

IF 3.2 3区医学 Q2 GENETICS & HEREDITY Journal of Assisted Reproduction and Genetics Pub Date : 2025-01-01 Epub Date: 2024-12-18 DOI:10.1007/s10815-024-03318-z

Norbert Gleicher, David H Barad, Pasquale Patrizio, Sonia Gayete-Lafuente, Andrea Weghofer, Zion Ben Rafael, Shizuko Takahashi, Demián Glujovsky, Ben W Mol, Raoul Orvieto

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引用次数: 0

摘要

经过20多年PGT-A（及其前体）临床应用的逐步增加，美国生殖医学学会（ASRM）及其附属学会辅助生殖学会（SART）首次发表了一份委员会意见，明确承认“PGT-A作为体外受精（IVF）患者常规筛查试验的价值尚未得到证实。”这一声明是及时和受欢迎的，但需要一些补充，并提出了一些新的问题，其中为什么，如果PGT-A在普通人群中不能改善IVF周期结果，PGT-A的常规临床应用应该继续。

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An additive opinion to the committee opinion of ASRM and SART on the use of preimplantation genetic testing for aneuploidy (PGT-A).

After over 20 years of progressively increasing clinical utilization of PGT-A (and its precursors), the American Society for Reproductive Medicine (ASRM) and its daughter society, the Society for Assisted Reproduction (SART), for the first time published a committee opinion clearly acknowledging that "the value of PGT-A as a routine screening test for patients undergoing in vitro fertilization (IVF) has not been demonstrated." This statement is timely and welcome but requires some additions and raises some new questions, among those why, if PGT-A in a general population does not improve IVF cycle outcomes, the routine clinical utilization of PGT-A should continue.

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.