Cover Picture: Analysis of Macromolecular Size Distributions in Concentrated Solutions (Chem. Methods 12/2024)

The Front Cover shows Wiener skewing in sedimentation velocity boundary of highly concentrated macromolecular solutions. The transient refractive index gradient produces an optical aberration that can be recognized by the displacement of the Rayleigh interference optical baseline features associated with the migrating refractive index gradient. The red lines represent two select baseline blips with best-fit translation and slope. Global analysis of the translation versus slope data reveals the magnitude of Wiener skewing, which then can be modeled in the sedimentation analysis. More information can be found in the Research Article by Sumit K. Chaturvedi and Peter Schuck (DOI: 10.1002/cmtd.202400035).