福建省艾滋病住院患者入院时静息心率与60天全因死亡率之间的u型关系:一项回顾性队列研究。

IF 2.1 4区 医学 Q3 INFECTIOUS DISEASES AIDS Research and Therapy Pub Date : 2024-12-18 DOI:10.1186/s12981-024-00678-5
Rui Huang, Yan Li, Ling Chen, Yan Yang, Jinxiu Wang, Huan Zhao, Lifen Han
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引用次数: 0

摘要

背景:静息心率(RHR)升高与健康个体和人类免疫缺陷病毒(HIV)或获得性免疫缺陷综合征(AIDS)患者的不良预后相关。本研究旨在探讨入院时静息心率(RHR)与60天死亡率之间的关系。方法:本研究采用单中心回顾性队列研究,评估RHR对中国东南地区艾滋病患者60天死亡率的影响。2016年1月至2021年12月期间首次入院的艾滋病患者共2188例。RHR被划分为几类。使用60天死亡率估计疾病进展。采用Cox比例风险回归模型评价RHR与疾病进展的关系,采用两分段Cox回归模型揭示入院时RHR对60天死亡率的影响。结果:我们观察到RHR与60天死亡率呈u型关系。对于超过90 bpm的患者,60天死亡率迅速上升,多变量调整优势比(OR)为1.032(95%置信区间[CI 1.016-1.048, P])。结论:本研究确定了RHR与HIV/AIDS患者60天死亡率之间的u型关系。需要进一步研究RHR在及时预防艾滋病毒/艾滋病患者死亡方面的作用。
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TheU-shape association between on-admission resting heart rate and 60-day all-cause mortality of AIDS inpatients in Fujian China: a retrospective cohort study.

Background: An elevated resting heart rate (RHR) is associated with poor outcomes in both healthy individuals and those with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). This study aimed to investigated the association between on admission resting heart rate (RHR) and 60-day mortality.

Methods: This single-center retrospective cohort study evaluated the effect of RHR on the 60-day mortality of patient with AIDS in Southeast China. A total of 2188 patients with AIDS admitted for the first time between January 2016 and December 2021 were included. The RHR was categorized into tertiles. Disease progression was estimated using 60-day mortality rates. Cox proportional hazards regression models were used to evaluate the RHR with disease progression, and a two-piecewise Cox regression model was used to reveal the RHR effect at admission on 60-day mortality.

Results: We observed a U-shape relationship between RHR and 60-day mortality. For a above 90 bpm, the 60-day mortality rose rapidly with a multivariable adjusted odds ratio (OR) of 1.032 (95% confidence interval [CI 1.016-1.048, P < 0.001). Below the threshold, 60 days mortality decreased as the RHR increased to 90 bpm with a multivariate-adjusted OR of 0.943 (95% CI 0.904-0.984, P = 0.0065).

Conclusions: This study identified a U-shape relationship between RHR and 60-day mortality in HIV/AIDS patients. Further research is needed to characterize the role of RHR in the timely prevention of mortality in HIV/AIDS patients.

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来源期刊
AIDS Research and Therapy
AIDS Research and Therapy INFECTIOUS DISEASES-
CiteScore
3.80
自引率
4.50%
发文量
51
审稿时长
16 weeks
期刊介绍: AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered
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