1例cvid -肠病患者用ustekinumab成功治疗。

IF 3.3 4区医学 Q3 IMMUNOLOGY Immunologic Research Pub Date : 2024-12-18 DOI:10.1007/s12026-024-09559-5

Fenella Marley, Melanie Lockett, Mark Gompels, Alexandros Grammatikos

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引用次数: 0

摘要

CVID（常见可变免疫缺陷）与多种胃肠道疾病有关，包括那些模仿克罗恩病和溃疡性结肠炎的疾病。目前还没有明确的CVID治疗肠病的试验数据。没有具体的治疗建议；然而，它通常以与炎症性肠病类似的方式治疗，使用皮质类固醇、5-氨基水杨酸盐（5-ASA）、硫唑嘌呤和抗tnf治疗。我们报告一例54岁的cvd -肠病患者，在结肠活检中表现为腹泻和肉芽肿性炎症。在强的松龙、5-ASA和硫唑嘌呤治疗失败/不耐受后，他成功地接受了ustekinumab治疗。cvid -肠病的特征在临床和组织学上都有所改善，没有证据表明存在严重的治疗相关副作用。

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A patient with CVID-enteropathy successfully treated with ustekinumab.

CVID (common variable immunodeficiency) is associated with a variety of gastrointestinal disorders including those mimicking Crohn's disease and ulcerative colitis. At present there is no clear trial data for the treatment of CVID enteropathy. There are no specific recommendations for treatment; however, it is commonly treated in a similar manner to inflammatory bowel disease, with corticosteroids, 5-aminosalicylates (5-ASA), azathioprine and anti-TNF therapy all being used. We describe the case of a 54-year-old with CVID-enteropathy presenting with diarrhoea and evidence of granulomatous inflammation on colonic biopsies. He was successfully treated with ustekinumab following failure/intolerance of prednisolone, 5-ASA and azathioprine. Features of CVID-enteropathy improved both clinically and histologically, with no evidence of serious treatment-related side effects.

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来源期刊

Immunologic Research 医学-免疫学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.