Robbert J. Van der Pijl , Weikang Ma , Christopher T.A. Lewis , Line Haar , Amalie Buhl , Gerrie P. Farman , Marcus Rhodehamel , Vivek P. Jani , O Lynne Nelson , Chengxin Zhang , Henk Granzier , Julien Ochala
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Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears
Aim
The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals.
Methods
Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffraction and proteomics.
Main findings
Hibernating grizzly bears displayed an unusually high proportion of ATP-conserving super-relaxed cardiac myosin molecules that are likely due to altered levels of phosphorylation and rod region stability.
Conclusions
Cardiac myosin depresses the heart's energetic demand during hibernation by modulating its function.
期刊介绍：
Molecular Metabolism is a leading journal dedicated to sharing groundbreaking discoveries in the field of energy homeostasis and the underlying factors of metabolic disorders. These disorders include obesity, diabetes, cardiovascular disease, and cancer. Our journal focuses on publishing research driven by hypotheses and conducted to the highest standards, aiming to provide a mechanistic understanding of energy homeostasis-related behavior, physiology, and dysfunction.
We promote interdisciplinary science, covering a broad range of approaches from molecules to humans throughout the lifespan. Our goal is to contribute to transformative research in metabolism, which has the potential to revolutionize the field. By enabling progress in the prognosis, prevention, and ultimately the cure of metabolic disorders and their long-term complications, our journal seeks to better the future of health and well-being.
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