宫颈上皮内瘤变筛查和治疗中宿主细胞DNA甲基化标志物的临床适应症综述

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2024-12-16 DOI:10.1016/j.tvr.2024.200308

S. Dick , D.A.M. Heideman , J. Berkhof , R.D.M. Steenbergen , M.C.G. Bleeker

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摘要

宿主细胞基因的DNA甲基化是一种调控基因表达的表观遗传过程，与宫颈癌的发展有关。对宫颈上皮内瘤变（CIN）的自然史和与宫颈癌发生相关的分子改变的研究导致了几种宿主细胞DNA甲基化标记物的鉴定。近年来，关于甲基化标志物的各种研究在改善宫颈癌CIN筛查和管理方面的诊断和预后价值方面显示出令人鼓舞的结果。本文综述了宿主细胞DNA甲基化标志物在宫颈CIN筛查和管理中的临床适应症，并概述了进一步应用的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical indications for host-cell DNA methylation markers in cervical screening and management of cervical intraepithelial neoplasia: A review

DNA methylation of host-cell genes is an epigenetic process that regulates gene expression and is associated with cervical cancer development. Studies on the natural history of cervical intraepithelial neoplasia (CIN) and the molecular alterations associated with cervical carcinogenesis led to the identification of several host-cell DNA methylation markers. Over the past years, various studies on methylation markers have shown promising results in terms of diagnostic and prognostic value to improve cervical cancer screening and management of CIN. This review provides an overview of the clinical indications of host-cell DNA methylation markers in cervical screening and management of CIN, and outlines avenues for further applications.

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