基于上转换纳米粒子和氧化石墨烯的复合材料综述：以实体瘤为中心的开发和治疗应用

IF 3.4 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY International Journal of Mechanical and Materials Engineering Pub Date : 2024-12-20 DOI:10.1186/s40712-024-00187-3

Kabirdas B. Ghorpade, Manoj Kumar, Sanjay Tiwari

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摘要

上转换纳米颗粒（UCNPs）由于其独特的光学特性而引起了人们对实体肿瘤成像的极大兴趣。这些应用可以通过开发ucnp -氧化石墨烯（GO）复合材料扩展到抗癌治疗。该策略解决了UCNPs在生理介质中的低负载能力和分散性差的问题。本文已经讨论了这些方面。我们首先讨论了与UCNPs相关的合成方法和挑战，以及它们的表面改性策略。接下来，我们描述了设计UCNP-GO复合材料的方法及其在成像，生物传感和不同治疗平台中的应用。图形抽象

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A review on composites based on upconversion nanoparticles and graphene oxide: development and theranostic applications centered at solid tumors

Upconversion nanoparticles (UCNPs) have attracted considerable interest for the imaging of solid tumors because of their unique optical features. These applications can be expanded towards anticancer therapeutics by developing UCNP-graphene oxide (GO) composites. This strategy addresses low loading capacity and poor dispersibility of UCNPs in physiological media. These aspects have been covered in this article. We begin by discussing the synthesis methods and challenges associated with UCNPs, along with their surface modification strategies. Next, we describe the approaches of designing UCNP-GO composites and their applications in imaging, biosensing, and different therapeutic platforms.