用于关节软骨再生医学的可编程关节炎特异性受体

IF 7.2 2区医学 Q1 ORTHOPEDICS Osteoarthritis and Cartilage Pub Date : 2024-12-18 DOI:10.1016/j.joca.2024.12.002

Bonnie L. Walton, Rebecca Shattuck-Brandt, Catherine A. Hamann, Victoria W. Tung, Juan M. Colazo, David D. Brand, Karen A. Hasty, Craig L. Duvall, Jonathan M. Brunger

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引用次数: 0

摘要

研究细胞疗法已被开发为治疗骨关节炎（OA）的疾病调节剂，包括那些诱导对驱动OA进展的炎症因子作出反应的药物。然而，失调的炎症级联反应并不特别表明OA的存在。在这里，我们部署了一个合成受体平台，以关节炎特异性方式调节细胞行为，将转基因表达限制在软骨变性部位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine

Investigational cell therapies have been developed as disease-modifying agents for the treatment of osteoarthritis (OA), including those that inducibly respond to inflammatory factors driving OA progression. However, dysregulated inflammatory cascades do not specifically signify the presence of OA. Here, we deploy a synthetic receptor platform that regulates cell behaviors in an arthritis-specific fashion to confine transgene expression to sites of cartilage degeneration.

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.