妊娠期双侧股骨颈骨折提示甲状旁腺功能亢进患者髋关节短暂性骨质疏松症:1例报告。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Osteoporosis International Pub Date : 2024-12-24 DOI:10.1007/s00198-024-07346-4
Ryan J Blake, Vincent K Melemai, Brody M Fitzpatrick, David F Hubbard, Matthew J Dietz, Colleen M Watkins
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引用次数: 0

摘要

非外伤性双侧股骨颈骨折是罕见的,特别是在年轻患者和那些没有显著合并症。然而,由于钙平衡的正常生理变化,孕妇似乎风险增加,导致髋关节短暂性骨质疏松症。在这些个体中,钙和骨密度普遍降低,反映了胎儿发育对钙的需求。因此,围产期非骨质疏松性双侧股骨颈骨折仍然是一种罕见的表现。患者31岁,髋部疼痛加重;影像学检查显示双侧股骨颈骨折。分娩前11个月需要特殊操作的复杂分娩导致中度髋关节疼痛,分娩后约7个月从梯子底部台阶下一步导致髋关节疼痛急性加重。骨科评估确定患者将受益于手术固定双股骨颈,右侧关节置换术和左侧动态髋螺钉。患者的风湿病学评估显示,除了使用suboxone、吸烟和低水平的维生素d外,没有其他与骨质疏松症相关的危险因素。DXA扫描无显著性,有趣的是,唯一值得注意的实验室结果是甲状旁腺激素水平明显升高,钙含量略有增加。血清甲状旁腺激素水平高的孕妇不论血钙水平如何,都可能有发生非外伤性髋部骨折的危险,尤其是在对股骨颈施加压力时。本病例表明,在分娩后立即出现非典型髋部疼痛的患者中,临床怀疑髋部骨折和评估甲状旁腺功能亢进的重要性。
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Bilateral femoral neck fractures in pregnancy suggestive of transient osteoporosis of the hip in a patient with hyperparathyroidism: a case report.

Atraumatic bilateral femoral neck fractures are rare, especially in younger patients and those without significant comorbidities. However, pregnant individuals appear to be at increased risk due to normal physiological changes in calcium balance, leading to transient osteoporosis of the hip. In these individuals, calcium and bone mineral density are generally decreased, reflecting the calcium demands of the developing fetus. Therefore, peripartum non-osteoporotic bilateral femoral neck fractures sustained remain a rare presentation. A 31-year-old patient presented with worsening hip pain; imaging studies revealed bilateral femoral neck fractures. A complicated birth requiring specialized maneuvers 11 months prior resulted in moderate hip pain, and a single step down from the bottom rung of a ladder approximately 7 months after the delivery initiated acute exacerbation of the hip pain. Orthopedic evaluation determined that the patient would benefit most from the surgical fixation of both femoral necks with an arthroplasty on the right and a dynamic hip screw on the left. Rheumatologic evaluation of the patient revealed no relevant risk factors for osteoporosis other than suboxone use, tobacco use, and low levels of vitamin D. A DXA scan was unremarkable, and interestingly, the only notable laboratory findings were markedly increased parathyroid hormone levels with a slight increase in calcium. Pregnant patients with high serum levels of parathyroid hormone might be at risk for atraumatic hip fractures regardless of serum calcium levels, particularly when maneuvers that put stress on the femoral neck are employed. This case demonstrates the importance of increased clinical suspicion of hip fractures and evaluation for hyperparathyroidism in a patient presenting with atypical hip pain immediately following labor.

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来源期刊
Osteoporosis International
Osteoporosis International 医学-内分泌学与代谢
CiteScore
8.10
自引率
10.00%
发文量
224
审稿时长
3 months
期刊介绍: An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange of current ideas concerning the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition. While focusing on clinical research, the Journal will also accept submissions on more basic aspects of research, where they are considered by the editors to be relevant to the human disease spectrum.
期刊最新文献
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