LCRAnnotationsDB：一个低复杂度区域功能和结构注释数据库。

IF 3.7 2区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY BMC Genomics Pub Date : 2024-12-27 DOI:10.1186/s12864-024-10960-5

Joanna Ziemska-Legiecka, Patryk Jarnot, Sylwia Szymańska, Dagmara Błaszczyk, Alicja Staśczak, Hanna Langer-Macioł, Kinga Lucińska, Karolina Widzisz, Aleksandra Janas, Hanna Słowik, Wiktoria Śliwińska, Aleksandra Gruca, Marcin Grynberg

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引用次数: 0

摘要

低复杂性区（lcr）是氨基酸组成多样性较低的蛋白质片段。这些区域在蛋白质中起着重要作用。然而，描述这些功能的注释分散在数据库和科学文献中。LCRAnnotationsDB旨在整合关于lcr的知识，并将相关注释存储在一个地方。为了统一冗余注释，我们基于功能、蛋白质结构和生物过程的相似性对它们进行了分类。通过将类别与基因本体术语联系起来，将它们分层组织起来。可以通过https://lcrannotdb.lcr-lab.org/访问LCRAnnotationsDB数据库。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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LCRAnnotationsDB: a database of low complexity regions functional and structural annotations.

Low Complexity Regions (LCRs) are segments of proteins with a low diversity of amino acid composition. These regions play important roles in proteins. However, annotations describing these functions are dispersed across databases and scientific literature. LCRAnnotationsDB aims to consolidate knowledge about LCRs and store relevant annotations in a single place. To unify redundant annotations, we assigned them categories based on similarity in function, protein structure, and biological process. Categories are organized hierarchically by linking them to Gene Ontology terms. The LCRAnnotationsDB database can be accessed at https://lcrannotdb.lcr-lab.org/ .

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来源期刊

BMC Genomics 生物-生物工程与应用微生物

CiteScore

7.40

自引率

4.50%

发文量

769

审稿时长

6.4 months

期刊介绍： BMC Genomics is an open access, peer-reviewed journal that considers articles on all aspects of genome-scale analysis, functional genomics, and proteomics. BMC Genomics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.