YBX1:一种参与衰老和免疫调节的多功能蛋白。

IF 2.8 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Issues in Molecular Biology Pub Date : 2024-12-13 DOI:10.3390/cimb46120841
Wenze Zhang, Ying Liu, Zhe Zhao, Yizhi Zhang, Yujuan Liang, Wanxia Wang
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引用次数: 0

摘要

Y-box结合蛋白1 (YBX1)是一种多功能蛋白,在细胞生物学中具有广泛的作用。它在免疫调节、衰老和疾病进展中起关键作用。本文就YBX1在这些方面的具体功能和作用机制作一综述。最初,YBX1被证明与细胞衰老密切相关,并影响重要的生物过程,包括细胞增殖、损伤修复和代谢。这提示了在预防和治疗衰老相关疾病方面的潜在应用。此外,YBX1通过控制免疫细胞的功能和免疫分子的表达来调节免疫应答。它是维持免疫系统稳态所必需的,并影响包括肿瘤在内的各种疾病的病理过程。最后,YBX1蛋白的多种功能使其成为开发创新疾病治疗策略的有希望的候选者。对其机制的全面研究可为相关疾病的预防、诊断和治疗提供新的见解和途径。
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YBX1: A Multifunctional Protein in Senescence and Immune Regulation.

The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas. Initially, YBX1 is shown to be closely associated with cellular senescence and impacts significant biological processes, including cell proliferation, damage repair, and metabolism. This suggests potential applications in the prevention and treatment of senescence-related diseases. Additionally, YBX1 regulates the immune response by controlling the function of immune cells and the expression of immune molecules. It is essential in maintaining immune system homeostasis and impacts the pathological process of various diseases, including tumors. Lastly, the diverse functions of the YBX1 protein make it a promising candidate for the development of innovative therapeutic strategies for diseases. Comprehensive research on its mechanisms could provide novel insights and approaches for the prevention, diagnosis, and treatment of related diseases.

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来源期刊
Current Issues in Molecular Biology
Current Issues in Molecular Biology 生物-生化研究方法
CiteScore
2.90
自引率
3.20%
发文量
380
审稿时长
>12 weeks
期刊介绍: Current Issues in Molecular Biology (CIMB) is a peer-reviewed journal publishing review articles and minireviews in all areas of molecular biology and microbiology. Submitted articles are subject to an Article Processing Charge (APC) and are open access immediately upon publication. All manuscripts undergo a peer-review process.
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