Igor Stukalin, Mehul Gupta, Katherine Buhler, Nauzer Forbes, Steven J Heitman, Christopher Ma
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Annual percentage changes (APC) were estimated using joinpoint regression with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>In 2019, the incidence, mortality, and DALYs rates for EOCRC were 10.89 (95% UI 8.09, 14.34), 2.24 (95% UI 2.00, 2.51), and 111.37 (95% UI 99.34, 124.78) per 100,000 individuals, respectively. Incidence increased during the study period by 1.12%/year (95% CI 1.03%, 1.22%; <i>p</i> < 0.001). The largest increase in incidence in EOCRC occurred between 1990 and 2007, with an APC of 2.23% (95% CI 2.09%, 2.37%; <i>p</i> < 0.001). 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引用次数: 0
摘要
背景：结直肠癌是全球第三大常见恶性肿瘤。早发性结直肠癌（EOCRC）正在成为全球日益增长的医疗保健焦点，特别是在北美。我们估计了1990年至2019年间加拿大EOCRC的发病率、死亡率和残疾调整生命年（DALYs）的趋势。方法：我们使用全球疾病负担研究来评估1990年至2019年加拿大EOCRC发病率、死亡率和DALYs的趋势。估计每10万人中有风险的比率与相关的不确定区间（UIs）。使用95%置信区间（ci）的连接点回归估计年百分比变化（APC）。结果：2019年，EOCRC的发病率、死亡率和DALYs分别为10.89 （95% UI为8.09、14.34）、2.24 （95% UI为2.00、2.51）和111.37 (95% UI为99.34、124.78)/ 10万人。在研究期间，发病率增加了1.12%/年(95% CI 1.03%, 1.22%；P < 0.001)。EOCRC发病率的最大增长发生在1990 - 2007年间，APC为2.23% (95% CI 2.09%, 2.37%；P < 0.001)。死亡率(APC 2.95%, 95% CI 1.89%, 4.02%；p < 0.001)和DALY (APC 2.96%, 95% CI 1.84%, 4.09%；P < 0.001)，男性的发病率在2001年至2006年间有所上升。结论：我们的研究揭示了加拿大EOCRC的巨大负担，发病率显著增加。
Brief Report: Trends in Incidence, Mortality, and Disability-Adjusted Life Years for Early-Onset Colorectal Cancer in Canada Between 1990 and 2019.
Background: Colorectal cancer is the third most common malignancy globally. Early-onset colorectal cancer (EOCRC) is becoming a growing healthcare focus globally, particularly in North America. We estimated trends in incidence, mortality, and disability-adjusted life years (DALYs) for EOCRC in Canada between 1990 and 2019.
Methods: We used the Global Burden of Diseases Study to evaluate trends in incidence, mortality, and DALYs for EOCRC in Canada between 1990 and 2019. Rates were estimated per 100,000 persons at risk with associated uncertainty intervals (UIs). Annual percentage changes (APC) were estimated using joinpoint regression with 95% confidence intervals (CIs).
Results: In 2019, the incidence, mortality, and DALYs rates for EOCRC were 10.89 (95% UI 8.09, 14.34), 2.24 (95% UI 2.00, 2.51), and 111.37 (95% UI 99.34, 124.78) per 100,000 individuals, respectively. Incidence increased during the study period by 1.12%/year (95% CI 1.03%, 1.22%; p < 0.001). The largest increase in incidence in EOCRC occurred between 1990 and 2007, with an APC of 2.23% (95% CI 2.09%, 2.37%; p < 0.001). Mortality (APC 2.95%, 95% CI 1.89%, 4.02%; p < 0.001) and DALY (APC 2.96%, 95% CI 1.84%, 4.09%; p < 0.001) rates increased for males between 2001 and 2006.
Conclusions: Our study reveals a substantial burden in EOCRC in Canada, with a significant increase in incidence.
期刊介绍：
Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease.
We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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