基于TILs分级的PD-1和PD-L1作为结直肠癌预后和预测性生物标志物的潜力

IF 2.8 4区医学 Q2 ONCOLOGY Current oncology Pub Date : 2024-11-25 DOI:10.3390/curroncol31120552

Nur Rahmah Rasyid, Upik Anderiani Miskad, Muhammad Husni Cangara, Syarifuddin Wahid, Djumadi Achmad, Suryani Tawali, Mardiati Mardiati

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引用次数: 0

摘要

目的：结直肠癌（CRC）是一种常见的恶性肿瘤，死亡率高。肿瘤浸润淋巴细胞（til）在肿瘤免疫应答中起着至关重要的作用。程序性死亡-1 （PD-1）和程序性死亡配体1 （PD-L1）是肿瘤微环境中调节T细胞的关键免疫检查点。本研究旨在评估PD-1在TIL上的表达、肿瘤中PD-L1的表达以及结直肠癌TIL分级之间的关系。方法：采用横断面设计对130例结直肠癌样本进行分析。免疫组化检测PD-1和PD-L1的表达。采用半定量评分系统。采用卡方检验进行统计学分析以探讨相关性，数据采用SPSS version 27进行分析。结果：肿瘤组织中PD-1表达与TIL分级呈正相关（p < 0.001），肿瘤组织中PD-L1表达与TIL分级呈负相关（p < 0.001）。结论：肿瘤细胞上PD-1和PD-L1的表达与结直肠癌TILs的分级有显著相关性。这一发现显示了作为PD-1/PD-L1阻断治疗的预测性生物标志物的潜力。需要进一步的研究来加强这些结果。

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The Potential of PD-1 and PD-L1 as Prognostic and Predictive Biomarkers in Colorectal Adenocarcinoma Based on TILs Grading.

Aim: Colorectal cancer (CRC) is a prevalent malignancy with a high mortality rate. Tumor-infiltrating lymphocytes (TILs) play a crucial role in the immune response against tumors. Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are key immune checkpoints regulating T cells in the tumor microenvironment. This study aimed to assess the relationships among PD-1 expression on TILs, PD-L1 expression in tumors, and TIL grading in colorectal adenocarcinoma.

Methods: A cross-sectional design was employed to analyze 130 colorectal adenocarcinoma samples. The expression of PD-1 and PD-L1 was assessed through immunohistochemistry. A semi-quantitative scoring system was applied. Statistical analysis with the chi-square test was performed to explore correlations, with the data analyzed in SPSS version 27.

Results: PD-1 expression on TILs significantly correlated with a higher TIL grading (p < 0.001), while PD-L1 expression in tumors showed an inverse correlation with TIL grading (p < 0.001).

Conclusions: The expression of PD-1 on TILs and PD-L1 on tumor cells correlated significantly with the grading of TILs in colorectal adenocarcinoma. This finding shows potential as a predictive biomarker for PD-1/PD-L1 blockade therapy. Further studies are needed to strengthen these results.

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来源期刊

Current oncology ONCOLOGY-

CiteScore

3.30

自引率

7.70%

发文量

664

审稿时长

1 months

期刊介绍： Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.