早期社会隔离压力引起的自然行为的转变与成年后雌性大鼠的暴饮暴食有关。

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES Frontiers in Behavioral Neuroscience Pub Date : 2024-12-12 eCollection Date: 2024-01-01 DOI:10.3389/fnbeh.2024.1519558
Timothy B Simon, Julio Sierra, Arianna Williams, Giara Wright, Allison Rhee, Julius Horn, John Lou, Fransua Sharafeddin, Perla Ontiveros-Ángel, Johnny D Figueroa
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引用次数: 0

摘要

暴饮暴食(BE)是一种非常普遍的适应不良应对策略,用于应对早期生活中严重的压力,如情感和社会忽视。BE被描述为反复发作的不受控制的饮食,并与共病的精神健康问题密切相关。尽管社会压力源发生在年轻时,但BE通常直到成年后才发病,这为潜在的治疗干预提供了间隔时间。目前,我们对预测BE的纵向无创数字生物标志物的了解需要进一步发展。监测青少年社会隔离压力对大鼠自然行为的纵向影响,将使疾病进展的非侵入性数字标记识别能够预测成年饮食策略。认识到青少年受社会压力影响的自然行为,有助于我们了解受影响最大的潜在神经回路。本研究旨在监测和识别纵向行为转变,以提高大鼠社会隔离应激性脑梗死模型的预测能力。我们将配对雌性大鼠(n = 12)和社会隔离雌性大鼠(n = 12)置于观察家养笼子中,每周观察7周,以评估社会隔离对10种自然行为的影响。采用Noldus Ethovision XT自动识别软件同时检测和跟踪所有10种自然行为。综合表型z分数通过标准化所有10种行为来计算。成年后,所有大鼠都接受了常规的情绪测试,并接受了西式高脂肪饮食(WD, 43%卡路里来自脂肪)来评估BE。纵向评估显示SI诱导青少年表型z分数的变化,嗅探、无支撑的饲养、跳跃和抽搐最容易受到SI的影响。与配对对照组相比,SI增加了情绪。最后,我们确定青少年抽搐是成人WD消费的数字生物标志物。我们的研究结果表明,家庭笼监测可以发现与不适应应对相关的破坏自然行为。
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Shifts in naturalistic behaviors induced by early social isolation stress are associated with adult binge-like eating in female rats.

Binge eating (BE) is a highly pervasive maladaptive coping strategy in response to severe early life stress such as emotional and social neglect. BE is described as repeated episodes of uncontrolled eating and is tightly linked with comorbid mental health concerns. Despite social stressors occurring at a young age, the onset of BE typically does not occur until adulthood providing an interval for potential therapeutic intervention. Currently, our knowledge of longitudinal noninvasive digital biomarkers predictive of BE needs further development. Monitoring longitudinal impacts of adolescent social isolation stress on naturalistic behaviors in rats will enable the identification of noninvasive digital markers of disease progression to predict adult eating strategies. Recognizing adolescent naturalistic behaviors shaped by social stress informs our understanding of the underlying neurocircuits most effected. This study aimed to monitor and identify longitudinal behavioral shifts to enhance predictive capabilities in a rat model of social isolation stress-induced BE. We placed Paired (n = 12) and Socially Isolated (SI, n = 12) female rats in observational home cages weekly for seven weeks to evaluate the effect of SI on 10 naturalistic behaviors. All 10 naturalistic behaviors were simultaneously detected and tracked using Noldus Ethovision XT automated recognition software. Composite phenotypic z-scores were calculated by standardizing all 10 behaviors. When transitioning into adulthood, all rats underwent conventional emotionality testing and were exposed to a Western-like high fat diet (WD, 43% kcal from fat) to evaluate BE. Longitudinal assessments revealed SI-induced shifts in adolescent phenotypic z-scores and that sniffing, unsupported rearing, jumping, and twitching were the most susceptible to SI. SI increased emotionality compared to the Paired controls. Finally, we identified adolescent twitching as a digital biomarker of adult WD consumption. Our findings suggest that home cage monitoring can detect disrupted naturalistic behaviors associated with maladaptive coping.

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来源期刊
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
4.70
自引率
3.30%
发文量
506
审稿时长
6-12 weeks
期刊介绍: Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.
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