Charles Nkansah, Felix Osei-Boakye, Samuel K. Appiah, Gabriel Abbam, Moses Banyeh, Samira Daud, Richard V. Duneeh, Simon B. Bani, Boniface N. Ukwah, Charles A. Derigubah, Victor U. Usanga, Emmanuel Appiah-Kubi, Ejike F. Chukwurah
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引用次数: 0
摘要
背景：ABO和Rh血型系统是国际输血学会认可的最重要的血型系统，广泛用于临床和人类学目的。本系统综述确定了加纳ABO和Rh(D)抗原的分布和等位基因频率。方法：文献检索在PubMed、b谷歌Scholar、Web of Science和ScienceDirect中进行，检索时间截止到2024年2月20日，包括2000年至2024年在加纳所有地区发表的研究。用于检索首选文献的搜索词是“血型/抗原”和“ABO和Rh(D)”和“分布/频率/患病率”，再加上加纳不同地区/区/市的名称。从所有地区加入相似血型的个体，并收集全国范围内的数据。采用Hardy-Weinberg模型估计血液抗原的等位基因频率。结果：加纳人群以O型血为主（54.72%），其次为B型血（21.74%）、A型血（19.65%）、AB型血（3.89%）。Rh(D)抗原阳性率为92.28%,Rh(D)阴性阳性率仅为7.72%。IA(p)、IB(q)、i(r)、ID(v)和ID(u)的A、B、O、Rh(D)阳性和Rh(D)阴性的等位基因频率分别为0.1227、0.1376、0.7397、0.7222和0.2778。结论：加纳ABO血型表型频率为O b> B>A>AB型，Rh(D)阴性血型患病率为7.72%。未来的全国性研究建议评估ABO， Rh和其他血型系统的分布。
Phenotypic and Allelic Frequencies of ABO and Rh(D) Blood Antigens in Ghana: A Systematic Review
Background
ABO and Rh blood group systems are the most significant blood group systems recognized by the International Society of Blood Transfusion and are widely used for clinical and anthropological purposes. This systematic review determined the distribution and allelic frequency of ABO and Rh(D) antigens in Ghana.
Methods
Literature searches were performed in PubMed, Google Scholar, Web of Science, and ScienceDirect, up to February 20, 2024, and included studies published from 2000 to 2024 in all regions of Ghana. The search terms used to retrieve the preferred literature were “Blood Group/Antigen” and “ABO and Rh(D)” and “Distribution/Frequency/Prevalence,” coupled with the names of the different regions/districts/municipalities in Ghana. Similar blood group individuals from all the regions were added, and countrywide data were gathered. The Hardy−Weinberg model was used to estimate the allelic frequency of blood antigens.
Results
Blood group O (54.72%) was the predominant group in the Ghanaian population, followed by B (21.74%), A (19.65%), and AB (3.89%). Rh(D) antigen was present in 92.28% of the population, and only 7.72% were Rh(D) negative. The calculated allelic frequencies of A, B, O, Rh(D) positive, and Rh(D) negative were 0.1227, 0.1376, 0.7397, 0.7222, and 0.2778 for IA(p), IB(q), i(r), ID(v), and Id(u), respectively.
Conclusion
The phenotypic frequency of the ABO blood group occurred in the pattern O>B>A>AB, and the prevalence of the Rh(D) negative blood group was 7.72% in Ghana. Future nationwide studies are recommended to assess the distribution of ABO, Rh, and other blood group systems.
期刊介绍：
Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including:
• cellular and molecular immunology
• clinical immunology
• allergy
• immunochemistry
• immunogenetics
• immune signalling
• immune development
• imaging
• mathematical modelling
• autoimmunity
• transplantation immunology
• cancer immunology
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