Jie Zhang , Ge Zheng , Liqiong Chen , Xueke Guo , Xia Fang , Wenmei Zhang , Yan Tu , Kexin Sun , Zhuhua Cai
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引用次数: 0
摘要
背景：现有文献支持非典型磷脂抗体-抗磷脂酰丝氨酸/凝血酶原抗体（aPS/PT）与不良妊娠结局之间的关联。本研究旨在探讨aPS/PT与胎膜早破（PROM）的关系。方法：对408例至少发生过一次不明原因流产的孕妇进行回顾性队列研究。对她们进行aPS/PT、IgM和IgG检测，收集临床资料、检测结果和随访妊娠结局。结果：单因素和多因素回归分析均显示aPS/PT IgM或IgG与PROM呈正相关。在调整潜在混杂因素后，aPS/PT IgM和aPS/PT IgG的比值比（OR）值分别为1.03（95 % CI: 1-1.05, P = 0.025）和1.03（95 % CI: 1.01-1.06, P = 0.016）。将aPS/PT分为三组，第三分位的aPS/PT IgG与第一分位的比较，调整OR值为2.11（95 % CI: 1.11-4, P = 0.022）。亚组分析支持这些发现。曲线拟合显示aPS/PT IgM和aPS/PT IgG与PROM呈线性关系。结论：本研究提示aPS/PT IgG和aPS/PT IgM是早破膜的独立危险因素，且aPS/PT IgG比aPS/PT IgM具有更高的意义。
The relation of anti-phosphatidylserine/prothrombin antibodies and premature rupture of membranes: A retrospective cohort study
Background
Existing literature supports the association between atypical phospholipid antibodies - anti-phosphatidylserine/prothrombin antibodies (aPS/PT) and adverse pregnancy outcomes. This study aimed to investigate the relationship between aPS/PT and premature rupture of membranes (PROM).
Methods
A retrospective cohort study analysis was conducted on 408 pregnant women who had experienced at least one unexplained miscarriage. They were tested for aPS/PT IgM and IgG, and clinical data, test results, and follow-up pregnancy outcomes were collected.
Results
A positive correlation was observed between aPS/PT IgM or IgG and PROM in both single-factor and multi-factor regression analysis. After adjusting for potential confounders, the odds ratio (OR) values for aPS/PT IgM and aPS/PT IgG were 1.03 (95 % CI: 1–1.05, P = 0.025) and 1.03 (95 % CI: 1.01–1.06, P = 0.016) respectively. When aPS/PT was divided in three groups, djusted OR values for aPS/PT IgG of the third tertiles compared to the first tertiles (were 2.11(95 % CI: 1.11–4, P = 0.022). Subgroup analysis supported these findings. Curve fitting revealed a linear relationship between aPS/PT IgM and aPS/PT IgG with PROM.
Conclusion
This study suggests that aPS/PT IgG and aPS/PT IgM are independent risk factors for premature rupture of membranes, with aPS/PT IgG showing a higher significance compared to aPS/PT IgM.
期刊介绍：
Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction
The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology.
This encompasses normal and pathological processes of:
* Male and Female Reproductive Tracts
* Gametogenesis and Embryogenesis
* Implantation and Placental Development
* Gestation and Parturition
* Mammary Gland and Lactation.
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