Alhadi Almangush , Miia Ruuskanen , Jaana Hagström , Veli-Matti Kosma , Antti A. Mäkitie , Ilmo Leivo
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引用次数: 0
摘要
背景：三级淋巴结构（TLSs）与许多恶性肿瘤的预后有关。然而，TLSs在鼻咽癌（NPC）患者中的临床意义尚不清楚。材料和方法：在这项以全人群为基础的多中心研究中，共纳入115例接受鼻咽癌治疗的患者。患者在芬兰五所大学医院接受治疗。在常规苏木精和伊红（HE）染色切片上评估TLSs。结果：TLSs的存在与鼻咽癌患者的生存率显著相关。在多变量分析中，TLSs缺失与NPC疾病特异性生存率差有显著相关性，风险比（HR）为1.96（95 % CI 1.09-3.53, P = 0.025）。同样，TLSs缺失与较差的总生存相关，风险比为1.68（95 % CI 1.02-2.75, P = 0.040）。结论：TLSs可能与鼻咽癌患者的预后有关。鼻咽癌肿瘤的TLSs与良好的生存率相关。TLSs的评估有助于了解鼻咽癌的临床行为和制定治疗计划。
Tertiary lymphoid structures in nasopharyngeal carcinoma: A multi-institutional study
Background
Tertiary lymphoid structures (TLSs) associate with prognosis of many malignancies. However, the clinical significance of TLSs is not well-elucidated in nasopharyngeal carcinoma (NPC) patients.
Material and methods
In this whole population-based multicenter study, a total of 115 patients treated for NPC were included. The patients were treated at the five Finnish university hospitals. TLSs were assessed in routine hematoxylin and eosin (HE)-stained sections.
Results
Presence of TLSs associates significantly with improved survival in NPC. Absence of TLSs had a significant association with a poor disease-specific survival of NPC with a hazard ratio (HR) of 1.96 (95 % CI 1.09–3.53, P = 0.025) in the multivariable analysis. Similarly, absence of TLSs associated with worse overall survival with a HR of 1.68 (95 % CI 1.02–2.75, P = 0.040).
Conclusion
TLSs seem to be associated with prognosis of NPC patients. Having TLSs in NPC tumors correlates with good survival. The assessment of TLSs could aid in understanding the clinical behavior and in planning the treatment of NPC.
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Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.
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