808 nm光协同作用下聚(2-氨基酚)/金纳米颗粒增强阿霉素治疗黑色素瘤癌细胞的光敏活性

Naghmeh Sattarahmady, Zahra Kayani, Hossein Heli, Parsa Faghani-Eskandarkolaei, Hanieh Haghighi
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引用次数: 0

摘要

背景:光热疗法(PTT)是一种有效的、非侵入性的治疗方法,有望改善肿瘤细胞的治疗。PTT的基础是通过红外光照射激活光敏剂,在肿瘤区域产生热量和活性物质和细胞凋亡。目的:探讨聚(2-氨基酚)/金(P2AO/AuNPs)和多柔比星(DOX)光热/化疗对黑色素瘤癌细胞的影响。材料与方法:本实验研究合成了P2AO/AuNPs纳米颗粒,并将其与DOX混合作为光敏剂应用于C540 (B16-F10)黑色素瘤细胞系的光热/化疗。结果:在808 nm光照射下,P2AO/AuNPs在光照射、P2AO/AuNPs和阿霉素的协同作用下,产生热量和细胞毒性反应氧(ROS),同时增强DOX的治疗效果。用P2AO/AuNPs和DOX处理细胞导致坏死细胞显著增加至61%,而活细胞显著减少(39%)。结论:P2AO/AuNPs为光吸收提供平台,增强DOX的治疗效果。这项研究通过激光、P2AO、AuNPs和DOX联合获得的协同效应,证实了一种新的光热/化疗的适用性。
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Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light.

Background: Photothermal therapy (PTT) is one of the effective and non-invasive strategies which hold great promise for improving the treatment of cancer cells. PTT is based on activating a photosensitizer by infrared light irradiation and producing heat and reactive species and apoptosis in the tumor area.

Objective: The aim of this study was to investigate the effect of photothermal/chemotherapy on melanoma cancer cells using poly (2-amino phenol)/gold (P2AO/AuNPs) and doxorubicin (DOX).

Material and methods: In this experimental study, nanoparticles of P2AO/AuNPs were synthesized, and their mixture with DOX was applied as a photosensitizer for photothermal/chemotherapy of a C540 (B16-F10) melanoma cell line.

Results: P2AO/AuNPs generated heat and cytotoxic responsive oxygen species (ROS) upon 808-nm light irradiation with simultaneous intensifying DOX therapeutic effect under domination of synergism effects between light irradiation, P2AO/AuNPs, and doxorubicin. Cell treatment with both P2AO/AuNPs and DOX resulted in a considerable increase in necroptotic cells to 61% with a significant decrease in the living cells (39%).

Conclusion: P2AO/AuNPs provided a platform for light absorption and intensifying DOX therapeutic effect. This study approved the applicability of a new photothermal/chemotherapy by domination of synergistic effects attained by combination of laser light, P2AO, AuNPs, and DOX.

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来源期刊
Journal of Biomedical Physics and Engineering
Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
2.90
自引率
0.00%
发文量
64
审稿时长
10 weeks
期刊介绍: The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.
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Developing a Mobile Application for Estimating Patient's Radiation Dose. Biophoton and Tubulin: New Insights into the Etiology of Neurodegenerative Diseases. Comparison of X-Ray Attenuation Performance, Antimicrobial Properties, and Cytotoxicity of Silicone-Based Matrices Containing Bi2O3, PbO, or Bi2O3/PbO Nanoparticles. Investigation Myocardial Perfusion Scan Parameters and Walls Motion in Patients undergoing Cardiac Surgery. Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light.
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