{"title":"东亚跨欧亚爱泼斯坦-巴氏病毒毒株的基因组特征。","authors":"Hiroshi Kitamura , Iwao Kukimoto , Misako Yajima , Kazufumi Ikuta , Kenroh Sasaki , Teru Kanda","doi":"10.1016/j.virol.2024.110359","DOIUrl":null,"url":null,"abstract":"<div><div>More than 95% of adult humans worldwide are latently infected with Epstein-Barr virus (EBV). Recent studies indicated that different EBV strains colonize different regions of Asia, where nasopharyngeal carcinoma (NPC) is endemic (southern China) or non-endemic (Japan/Korea). We searched for viral single nucleotide variant markers throughout the EBV genome by comparing the coding sequences of Japanese/Korean and NPC-endemic Chinese strains. We identified BamHI D fragment leftward reading frame 1 (BDLF1)<em>,</em> BDLF2, and BDLF3 genes as viral geographical markers for distinguishing Japanese/Korean EBV strains from NPC-endemic Chinese EBV strains. Most significantly, BDLF-based EBV genotyping indicated that NPC-non-endemic Chinese and Mongolian EBV strains belong to the same group as Japanese/Korean EBV strains. We conclude that a particular type of EBV, designated as Transeurasian EBV, is prevalent among Transeurasian language speakers (Japanese, Korean, and Mongolian populations) and NPC-non-endemic Chinese populations.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"603 ","pages":"Article 110359"},"PeriodicalIF":2.8000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Distinct genomic features of Transeurasian strains of Epstein-Barr virus in East Asia\",\"authors\":\"Hiroshi Kitamura , Iwao Kukimoto , Misako Yajima , Kazufumi Ikuta , Kenroh Sasaki , Teru Kanda\",\"doi\":\"10.1016/j.virol.2024.110359\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>More than 95% of adult humans worldwide are latently infected with Epstein-Barr virus (EBV). Recent studies indicated that different EBV strains colonize different regions of Asia, where nasopharyngeal carcinoma (NPC) is endemic (southern China) or non-endemic (Japan/Korea). We searched for viral single nucleotide variant markers throughout the EBV genome by comparing the coding sequences of Japanese/Korean and NPC-endemic Chinese strains. We identified BamHI D fragment leftward reading frame 1 (BDLF1)<em>,</em> BDLF2, and BDLF3 genes as viral geographical markers for distinguishing Japanese/Korean EBV strains from NPC-endemic Chinese EBV strains. Most significantly, BDLF-based EBV genotyping indicated that NPC-non-endemic Chinese and Mongolian EBV strains belong to the same group as Japanese/Korean EBV strains. We conclude that a particular type of EBV, designated as Transeurasian EBV, is prevalent among Transeurasian language speakers (Japanese, Korean, and Mongolian populations) and NPC-non-endemic Chinese populations.</div></div>\",\"PeriodicalId\":23666,\"journal\":{\"name\":\"Virology\",\"volume\":\"603 \",\"pages\":\"Article 110359\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0042682224003830\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0042682224003830","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
Distinct genomic features of Transeurasian strains of Epstein-Barr virus in East Asia
More than 95% of adult humans worldwide are latently infected with Epstein-Barr virus (EBV). Recent studies indicated that different EBV strains colonize different regions of Asia, where nasopharyngeal carcinoma (NPC) is endemic (southern China) or non-endemic (Japan/Korea). We searched for viral single nucleotide variant markers throughout the EBV genome by comparing the coding sequences of Japanese/Korean and NPC-endemic Chinese strains. We identified BamHI D fragment leftward reading frame 1 (BDLF1), BDLF2, and BDLF3 genes as viral geographical markers for distinguishing Japanese/Korean EBV strains from NPC-endemic Chinese EBV strains. Most significantly, BDLF-based EBV genotyping indicated that NPC-non-endemic Chinese and Mongolian EBV strains belong to the same group as Japanese/Korean EBV strains. We conclude that a particular type of EBV, designated as Transeurasian EBV, is prevalent among Transeurasian language speakers (Japanese, Korean, and Mongolian populations) and NPC-non-endemic Chinese populations.
期刊介绍：
Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.
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